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Wei Guo

Associate Professor


Tenured Associate Professor              ZJU-UoE Institute, ZJU                                2017-Present

Tenure-track Associate Professor       Tsinghua University                                          2010-2017

Postdoctoral fellow University of California, Los Angeles, CA, USA                             2003-2010

University of Texas Graduate School of Biomedical Sciences, Houston, TX               1996-2002
Ph. D., Molecular Genetics

Chinese Academy of Sciences Institute of Microbiology, Beijing, China                      1992-1995
M.S., Biochemistry

Nankai University, Tianjin, China                                                                                  1988-1992
B.S., Microbiology

Jassen-Tsinghua Investigator Award                
Jassen-Tsinghua University, Beijing, China                                                                  2011-2013

Bayer Investigator Award,
Bayer-Tsinghua University, Beijing, China                                                                             2010

California Institute for Regenerative Medicine Training Grant
the California Institute for Regenerative Medicine & UCLA Institute for Stem Cell Biology and
Medicine, California, USA                                                                                             2006-2009

AACR-Merck Scholar-in-Training Award
American Association of Cancer Research 100th Annual Meeting, Denver, CO, USA         2009

Boyer-Parvin Award and Best Postdoctoral Research Excellence Award
University of California, Los Angeles, California, USA                                                           2008

AACR-Bristol-Myers Squibb Oncology Scholar-in-Training Award
American Association of Cancer Research 97th Annual Meeting, Washington DC, USA     2006

Keystone Symposia Scholarship
Keystone Hematopoiesis Symposium, Columbia British, Canada

Published Paper(*Correspongding Author, #the first author):

a. Zhang Y, Xu W, Guo H, Zhang Y, He Y, Lee SH, Song X, Li X, Guo Y, Zhao Y, Ding C, Ning F, Ma Y, Lei QY, Hu X, Li S* and Guo W*. NOTCH1 signaling regulates self-renewal and platinum chemoresistance of cancer stem-like cells in human non-small cell lung cancer. Cancer Res 2017;77: 3082-91

b. Yang M, Chen S, Du J, He J, Wang Y, Li Z, Liu G, Peng W, Zeng X, Li D, Xu P, Guo W, Chang Z, Wang S, Tian Z, and Dong Z. NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation. Nature Communications 7, 12730 (2016)

c. Schubbert S, Cardenas A, Chen H, Garcia C, Guo W, Bradner JE, and Wu H. Targeting the MYC and PI3K pathways eliminates leukemia-initiating cells in T cell acute lymphoblastic leukemia. Cancer Res 2014;74:7048-59

d. Li Z, Lan Y, He W, Chen D, Wang J, Zhou F, Wang Y, Sun H, Chen X, Xu C, Li S, Zhu L, Fan M, Shang A, Ju Z, Luo L, Ding Y, Guo W, Cheng T, Yang X, and Liu B. Mouse Embryonic Head as a Novel Site for Hematopoietic Stem Cell Development. Cell Stem Cell 2012;11:663-75.

e. Guo W#, Schubbert S, Chen JY, Valamehr B, Mosessian S, Shi H, Dang NH, Garcia C, Theodoro MF, Varella-Garcia M, and Wu H. Suppression of leukemia development caused by PTEN loss. PNAS 2011; 108: 1409-1414.

f. Guo W#, Lasky JL, Chang CJ, Mosessian S, Lewis X, Xiao Y, Yeh JE, Chen JY, Iruela-Arispe LM, Varella-Garcia M, and Wu H. Multi-genetic events collaboratively contribute to Pten null leukemia stem cell formation. Nature 2008; 453: 529-533.

g. Drakos E., Rassidakis GZ, Leventaki V, Guo W, Medeiros LJ and Nagarajan L. Differential expression of the human MIXL1 gene product in Non-Hodgkin's and Hodgkin's lymphomas. Hum Pathol 2007; 38(3):500-7.

h. Guo W#, Liang H and Nagarajan L. Amino terminal tyrosine phosphorylation of human MIXL1. J. Mol. Signaling 2006; 1:6.

i. Yilmaz OH, Valdez R, Threisen BK, Guo W, Ferguson DO, Wu H, Morrison SJ. Pten dependence distinguishes hematopoietic stem cells from leukemia initiating cells. Nature 2006; 441:475-82.

j. Guo W* Lasky JL, and Wu H. Cancer stem cells. Pediatr Res 2006; 59: 59-64.

k. Stiles BL, Kuralwalla-Martinez C, Guo W, Gregorian C, Wang Y, Tian J, Magnuson MA, Wu H. Selective deletion of Pten in pancreatic β cells leads to increased islet mass and resistance to STZ-Induced diabetes. Mol Cell Biol 2006; 26:2772-81.

l. Guo W#, Chan AP, Liang H, Wieder ED, Molldrem JJ, Etkin LD and Nagarajan L. A human Mix-like homeobox gene MIXL shows functional similarity to Xenopus Mix.1. Blood 2002; 100:89-95.

m. Jiang Y, Liang H, Guo W, Kottickal LV and Nagarajan L. Differential expression of a novel C-terminally truncated splice form of SMAD5 in hematopoietic stem cells and leukemia. Blood 2000; 95(12): 3945-50.

n. Liang H, Guo W and Nagarajan L. Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277. Genomics 2000; 66(2): 226-8.


Research interests: 
  1. Regulation and gene therapy of hematopoietic stem cells

  2. Regulation, drug resistance and targeted inhibition of tumor stem cells and tumor metastasis