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Hongwei Ouyang



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Professional Memberships:

Committee Member, Tissue Engineering and Regenerative MedicineInternational Society–Asia Pacific
Alternate Chairman,Chinese Society of Biomedical Engineering (Tissue Engineering and Regenerative Medicine Section)
Editorial Board member, Biomaterials
Chairman, Chinese Association of Orthopaedic Surgeons, Chinese Orthopeadic Regenerative Medicine Sociery
Vice chairman, Chinese Association of Orthopaedic Surgeons Based committee
Director, Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine
Chairman, Zhejiang Provincial Biomedical Society
Final expert, FP-7 fund
External evaluation experts, BBSRC Research Grant Council in UK
External evaluation experts, Research Grants Council (RGC) of Hong Kong
Vice-editor, “Systematic Anatomy”, People's Medical Publishing House




1. 国家重点研发计划(重点专项),干细胞体外自动化、规模化培养基扩增体系,2017-2021,项目负责人
2. 国家自然科学基金(重点项目),退行性骨关节炎的亚型识别和再生研究,2017-2021,项目负责人
3. 国家重点研发计划(重点专项),材料基因工程关键技术与支撑平台-软骨诱导材料的高通量制备、高通量评价和临床试验,2016-2020,项目负责人
4. 国家自然科学基金(重点项目),SCX+NES+肌腱干细胞亚群分化的转录调控研究,2014-2018,项目负责人
5. 浙江省科学技术厅(重点科技创新团队),肌肉骨骼系统组织工程与再生医学技术创新团队,2014-2016,项目负责人
6. 国家高技术研究发展计划(863计划),组织再生关键实用技术和前瞻技术及产品研发,2012-2015,项目负责人 
7. 国家自然科学基金(杰出青年科学基金),运动医学,2012-2015,项目负责人



Represeantative publications and corresponding author:


Stem cell and sport medicine:
1.        Yin, Z; Hu, JJ; Yang, L; Zheng, ZF; An, CR; Wu, BB; Zhang, C; Shen, WL; Liu, HH; Chen, JL; Heng, BC; Guo, GJ; Chen, X; Ouyang, HW, Single-cell analysis reveals a nestin(+) tendon stem/progenitor cell population with strong tenogenic potentiality, SCIENCE ADVANCES, 2016;2(11), doi:e1600874,10.1126/sciadv.1600874 Science子刊
2.        Jun Dai, Dongsheng Yu, Yafei Wang, Yishan Chen, Heng Sun, Xiaolei Zhang, Shouan Zhu, Zongyou Pan, Boon Chin Heng, Shufang Zhang, Hongwei Ouyang, Kdm6b regulates cartilage development and homeostasis through anabolic metabolism. ANNALS OF THE RHEUMATIC DISEASES, 2016; 0:1-9, doi:10.1136/annrheumdis-2016-210407 IF:12.384
3.        Zhu, SA; Lu, P; Liu, HH; Chen, PF; Wu, Y; Wang, YY; Sun, H; Zhang, XL; Xia, QQ; Heng, BC; Zhou, YT; Ouyang, HW, Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo, ANNALS OF THE RHEUMATIC DISEASES, 2015;74(1):285-293, doi:10.1136/annrheumdis-2013-203901 被Nature Review Rheum highlight, 获得2013年软骨学会年度最优秀论文奖 IF:12.384
4.        Jiang, YZ; Cai, YZ; Zhang, W; Yin, Z; Hu, CC; Tong, T; Lu, P; Zhang, SF; Neculai, D; Tuan, RS; Ouyang, HW, Human Cartilage-Derived Progenitor Cells From Committed Chondrocytes for Efficient Cartilage Repair and Regeneration, STEM CELLS TRANSLATIONAL MEDICINE, 2016;5(6):733-744, doi:10.5966/sctm.2015-0192 STEM CELLS高亮引用并在2016年8月被国家基金委制作专门简报关节炎软骨修复与再生报送中央各部门。
5.        Hu, JJ; Yin, Z; Shen, WL; Xie, YB; Zhu, T; Lu, P; Cai, YZ; Kong, MJ; Heng, BC; Zhou, YT; Chen, WS; Chen, X; Ouyang, HW, Pharmacological Regulation of In Situ Tissue Stem Cells Differentiation for Soft Tissue Calcification Treatment, STEM CELLS, 2016
6.        Liu, HH; Zhang, C; Zhu, SA; Lu, P; Zhu, T; Gong, XN; Zhang, ZW; Hu, JJ; Yin, Z; Heng, BC; Chen, X; Ouyang, HW, Mohawk Promotes the Tenogenesis of Mesenchymal Stem Cells Through Activation of the TGF beta Signaling Pathway, STEM CELLS, 2015
7.        Yin, Z; Guo, J; Wu, TY; Chen, X; Xu, LL; Lin, SE; Sun, YX; Chan, KM; Ouyang, HW; Li, G,Stepwise Differentiation of Mesenchymal Stem Cells Augments Tendon-Like Tissue Formation and Defect Repair In Vivo, STEM CELLS TRANSLATIONAL MEDICINE, 2016
8.        Zhu, SA; Chen, PF; Wu, Y; Xiong, S; Sun, H; Xia, QQ; Shi, LB; Liu, HH; Ouyang, HW, Programmed Application of Transforming Growth Factor beta 3 and Rac1 Inhibitor NSC23766 Committed Hyaline Cartilage Differentiation of Adipose-Derived Stem Cells for Osteochondral Defect Repair, STEM CELLS TRANSLATIONAL MEDICINE, 2014
9.        Shen, WL; Chen, JL; Zhu, T; Chen, LK; Zhang, W; Fang, Z; Heng, BC; Yin, Z; Chen, X; Ji, JF; Chen, WS; Ouyang, HW, Intra-Articular Injection of Human Meniscus Stem/Progenitor Cells Promotes Meniscus Regeneration and Ameliorates Osteoarthritis Through Stromal Cell-Derived Factor-1/CXCR4-Mediated Homing, STEM CELLS TRANSLATIONAL MEDICINE, 2014
10.     Xia, QQ; Zhu, SA; Wu, Y; Wang, JQ; Cai, YZ; Chen, PF; Li, J; Heng, BC; Ouyang, HW; Lu, P, Intra-Articular Transplantation of Atsttrin-Transduced Mesenchymal Stem Cells Ameliorate Osteoarthritis Development, STEM CELLS TRANSLATIONAL MEDICINE, 2015
11.     Zhu, SA; Dai, J; Liu, HH; Cong, XX; Chen, YS; Wu, Y; Hu, H; Heng, BC; Ouyang, HW; Zhou, YT, Down-Regulation of Rac GTPase-Activating Protein OCRL1 Causes Aberrant Activation of Rac1 in Osteoarthritis Development, ARTHRITIS & RHEUMATOLOGY, 2015

 biomaterials and musculoskeletal tissue engineering:
1.        Wu, Y; Zhu, SA; Wu, CT; Lu, P; Hu, CC; Xiong, S; Chang, J; Heng, BC; Xiao, Y; Ouyang, HW, A Bi-Lineage Conducive Scaffold for Osteochondral Defect Regeneration, ADVANCED FUNCTIONAL MATERIALS, 2014;24(28): 4473-4483, doi:10.1016/j.biomaterials.2015.02.071, IF:11.382
2.        Yin, Z; Chen, X; Song, HX; Hu, JJ; Tang, QM; Zhu, T; Shen, WL; Chen, JL; Liu, HH; Heng, BC; Ouyang, HW, Electrospun scaffolds for multiple tissues regeneration in vivo through topography dependent induction of lineage specific differentiation, BIOMATERIALS, 2015; 44: 173-185, doi:10.1016/j.biomaterials.2015.04.060, Top ESI 1%
3.        Liu, HH; Peng, HJ; Wu, Y; Zhang, C; Cai, YZ; Xu, GW; Li, Q; Chen, X; Ji, JF; Zhang, YZ; OuYang, HW, The promotion of bone regeneration by nanofibrous hydroxyapatite/chitosan scaffolds by effects on integrin-BMP/Smad signaling pathway in BMSCs, BIOMATERIALS, 2013; 34(18):4404-4417, doi:10.1016/j.biomaterials.2015.02.051, Top ESI 1%
4.        Wang, JJ; Wang, JQ; Lu, P; Cai, YZ; Wang, YF; Hong, L; Ren, H; Heng, BC; Liu, H; Zhou, J; Ouyang, HW, Local delivery of FTY720 in PCL membrane improves SCI functional recovery by reducing reactive astrogliosis, BIOMATERIALS, 2015
5.        Chen, X; Gu, S; Chen, BF; Shen, WL; Yin, Z; Xu, GW; Hu, JJ; Zhu, T; Li, G; Wan, C; Ouyang, HW; Lee, TL; Chan, WY, Nanoparticle delivery of stable miR-199a-5p agomir improves the osteogenesis of human mesenchymal stem cells via the HIF1a pathway, BIOMATERIALS, 2015
6.        Zhang, C; Yuan, HH; Liu, HH; Chen, X; Lu, P; Zhu, T; Yang, L; Yin, Z; Heng, BC; Zhang, YZ; Ouyang, HW, Well-aligned chitosan-based ultrafine fibers committed teno-lineage differentiation of human induced pluripotent stem cells for Achilles tendon regeneration, BIOMATERIALS, 2015
7.        Chen, PF; Tao, JD; Zhu, SA; Cai, YZ; Mao, QJ; Yu, DS; Dai, J; Ouyang, HW, Radially oriented collagen scaffold with SDF-1 promotes osteochondral repair by facilitating cell homing, BIOMATERIALS, 2015
8.        Shen, WL; Chen, X; Hu, YJ; Yin, Z; Zhu, T; Hu, JJ; Chen, JL; Zheng, ZF; Zhang, W; Ran, JS; Heng, BC; Ji, JF; Chen, WS; Ouyang, HW, Long-term effects of knitted silk-collagen sponge scaffold on anterior cruciate ligament reconstruction and osteoarthritis prevention, BIOMATERIALS, 2014
9.        Ren, H; Han, M; Zhou, J; Zheng, ZF; Lu, P; Wang, JJ; Wang, JQ; Mao, QJ; Gao, JQ; Ouyang, HW, Repair of spinal cord injury by inhibition of astrocyte growth and inflammatory factor synthesis through local delivery of flavopiridol in PLGA nanoparticles, BIOMATERIALS, 2014
10.     Chen, PF; Zhu, SA; Wang, YY; Mu, Q; Wu, Y; Xia, QQ; Zhang, XL; Sun, H; Tao, JD; Hu, H; Lu, P; Ouyang, HW, The amelioration of cartilage degeneration by ADAMTS-5 inhibitor delivered in a hyaluronic acid hydrogel, BIOMATERIALS, 2014
11.     Shi, LB; Cai, HX; Chen, LK; Wu, Y; Zhu, SA; Gong, XN; Xia, YX; Ouyang, HW; Zou, XH, Tissue engineered bulking agent with adipose-derived stem cells and silk fibroin microspheres for the treatment of intrinsic urethral sphincter deficiency, BIOMATERIALS, 2014
12.     Zhang, W; Chen, JL; Tao, JD; Hu, CC; Chen, LK; Zhao, HS; Xu, GW; Heng, BC; Ouyang, HW, The promotion of osteochondral repair by combined intra-articular injection of parathyroid hormone-related protein and implantation of a bi-layer collagen-silk scaffold, BIOMATERIALS, 2013
13.     Zhang, W; Chen, JL; Tao, JD; Jiang, YZ; Hu, CC; Huang, L; Ji, JF; Ouyang, HW, The use of type 1 collagen scaffold containing stromal cell-derived factor-1 to create a matrix environment conducive to partial-thickness cartilage defects repair, BIOMATERIALS, 2013
14.     Wang, W; Li, B; Yang, JZ; Xin, L; Li, YL; Yin, HP; Qi, YY; Jiang, YZ; Ouyang, HW; Gao, CY, The restoration of full-thickness cartilage defects with BMSCs and TGF-beta 1 loaded PLGA/fibrin gel constructs, BIOMATERIALS, 2010
15.     Chen, JL; Yin, Z; Shen, WLA; Chen, XA; Heng, BC; Zou, XAH; Ouyang, HW, Efficacy of hESC-MSCs in knitted silk-collagen scaffold for tendon tissue engineering and their roles, BIOMATERIALS, 2010
16.     Shen, WL; Chen, XA; Chen, JL; Yin, Z; Heng, BC; Chen, WS; Ouyang, HW, The effect of incorporation of exogenous stromal cell-derived factor-1 alpha within a knitted silk-collagen sponge scaffold on tendon regeneration, BIOMATERIALS, 2010
17.     Wang, W; Li, B; Li, YL; Jiang, YZ; Ouyang, HW; Gao, CY, In vivo restoration of full-thickness cartilage defects by poly(lactide-co-glycolide) sponges filled with fibrin gel, bone marrow mesenchymal stem cells and DNA complexes, BIOMATERIALS, 2010
18.     Zou, XH; Zhi, YL; Chen, X; Jin, HM; Wang, LL; Jiang, YZ; Yin, Z; Ouyang, HW, Mesenchymal stem cell seeded knitted silk sling for the treatment of stress urinary incontinence, BIOMATERIALS, 2010
19.     Yin, Z; Chen, X; Chen, JL; Shen, WL; Nguyen, TMH; Gao, L; Ouyang, HW, The regulation of tendon stem cell differentiation by the alignment of nanofibers, BIOMATERIALS, 2010
20.     Chen, X; Qi, YY; Wang, LL; Yin, Z; Yin, GL; Zou, XH; Ouyang, HW, Ligament regeneration using a knitted silk scaffold combined with collagen matrix, BIOMATERIALS, 2008
21.     Wu, YN; Yang, Z; Hui, JHP; Ouyang, HW; Lee, EH, Cartilaginous ECM component-modification of the micro-bead culture system for chondrogenic differentiation of mesenchymal stem cells, BIOMATERIALS, 2007


Research interests: 
  1. Tendon Regeneration Science and Tissue Engineering Research
  2. Cartilage Regeneration Science and Tissue Engineering Research
  3. Biomedical Material Study on Mending Human Motion System Injuries