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Faculty


Associate Professor

aelhashash@hotmail.com






Biography:

Professor Ahmed Hashash has completed his PhD from Manchester University, UK. He is a fellow of the California Institute of Regenerative Medicine (CIRM) and New York University Medical School (MSSM), USA. Prof. Ahmed Hashash worked as a senior biomedical research scientist at Mount Sinai School of Medicine of New York University and Children’s Hospital Los Angeles. He was Assistant Professor and Principal Investigator of Stem Cell & Regenerative Medicine at Keck School of Medicine and Ostrow School of Dentistry of The University of Southern California, USA. In 2016, Prof. Hashash has joined The University of Edinburgh, Edinburgh Medical School-Zhejiang International Campus, (ZJU) as Tenure-Track Associate Professor and Senior Principal Investigator of Biomedicine, Stem Cell & Regenerative Medicine. He is also adjunct Professor at the School of Basic Medical Science and School of Medicine, Zhejiang University. Prof. Hashash has several breakthrough discoveries in genes/enzymes that control stem cell behavior and regenerative medicine. He has published more than 25 papers in reputed international journals and serving as an editorial board member of repute. Prof. El-Hashash acts as a discussion leader at the prestigious Gordon Research Seminar/Conference in USA, and a Peer Reviewer/ International Extramural Review for The Medical Research Council (MRC) grant applications, London, UK. He is invited to speak at several international conferences in USA, Spain, Greece, Egypt and China. He is the editor or author of several books on stem cell and regenerative medicine.


Research Interests:

Stem Cell, Regenerative Medicine, Biomedicine, 

Stem Cell Therapy of Diseases  & Cell and Developmental Biology


Research Topics:

1.The functional role of transcription factors and protein phosphatases in both kidneyand lung development, repair and regeneration.

2.Molecular mechanisms involved in lung diseases such asthma, COPD and acute lung injury (ALI) and congenital lung abnormalities.

3.Identification of the genetic and molecular regulation of lung stem cell fate decisions and the balance between self-renewal and differentiation during normal development and during the disease process.

4.Analysis of molecular mechanisms that direct endogenous lung stem cells to generate any lung epithelial cell type, as a means for developing novel approaches to ameliorate human pulmonary disease.


Research Discovery Media Press Releases:

-http://www.chla.org/press-release/researchers-children-s-hospital-los-angeles-identify-key-aspect-lung-epithelial

-http://respiratory-care-sleep-medicine.advanceweb.com/News/Industry-News/Mechanism-Critical-to-Lung-Formation-and-Regeneration-Identified.aspx

-http://www.news-medical.net/news/20120703/Scientists-discover-Eya1-enzyme-control-of-pulmonary-barrier-integrity.aspx

-http://www.chla.org/press-release/investigators-the-saban-research-institute-children-s-hospital-los-angeles-discover

-http://news.usc.edu/30958/Essential-Enzyme-for-Healthy-Lung-Development-Discovered/

-https://www.eurekalert.org/pub_releases/2011-03/chla-ide032911.php

-https://medicalxpress.com/news/2011-03-enzyme-essential-healthy-lung.html

AHMEND MEDIA.png

Selected Publications:

1. Berika M, Elgayyar M and El-Hashash A*. Asymmetric cell divisions of stem cells in the lung and other systems. Front Cell Dev Biol. (Stem Cell Treatments) 2014, 2:33. * Senior & Corresponding author

2. Lu K, Reddy R, Berika M, Warburton D, and El-Hashash A*. Abrogation of Six1/Eya1 disrupts the saccular phase of lung morphogenesis and cause remodeling. Dev Biol. 2013, 382: 110–123.* Senior & Corresponding author

3. El-Hashash A*, Turcatel G, Varma, S, Berika M, Alam D, and Warburton D. Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium. J Cell Sci. 2012, 125(Pt17): 4036-48. * Corresponding author

4. El-Hashash A* and Warburton D. Numb expression and asymmetric versus symmetric cell division in embryonic distal lung epithelium. J Histochem Cytochem. 2012, 60(9): 675-82. *Corresponding author

5. Turcatel G, Rubin N, El-Hashash AH and Warburton D. MIR-99a and MIR-99b modulate TGF-β induced epithelial to mesenchymal transition and regulate epithelial plasticity in murine mammary gland. Plos One 2012, 7(1):e31032.

6. El-Hashash A*, Turcatel G, Alam D, Buckley S, Bellusci S and Warburton D. Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development 2011,138(7): 1395-407. *Corresponding author

7. NieXu J, El-Hashash AH, Xu PX. Six1 regulates Grem1 expression in the meta-nephricmesenchyme to initiate branching morphogenesis. Dev Biol. 2011, 352(1):141-51.

8. El-Hashash A*, Alam D, Turcatel G, Bellusci S and Warburton D. Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the lung. Dev Biol. 2011, 353 (2): 242-258. *Corresponding author

9. El-Hashash A* , Warburton D. Cell polarity and spindle orientation in the distal epithelium of embryonic lung. Dev Dyn. 2011, 240(2):441-5. *Corresponding author

10. El-Hashash A, Alam D, Turcatel G, Bellusci S and Warburton D. Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol. 2010, 350(1):112-26.

11. Warburton D, El-Hashash A, Carraro G, Kemp P, Ricardi D, Bellusci S Shi W and Jesudason E (2010). Lung pattern formation, growth and development. Curr Top Dev Biol 90:73-158.

12. Carraro G, El-Hashash A, Guidolin D, Tiozzo C and Warburton D (2009). miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution. Dev Biol. 333(2): 238-50.

13. El-Hashash A, Warburton D and Kimber SJ (2009). Genes and signals regulating murine trophoblast cell development. Mech Dev. 127(1-2): 1-20.

14. El-Hashash, A and Kimber SJ (2006): PTHrP induces changes in cell cytoskeleton and E-cadherin, and regulates Eph/Ephrin kinases and RhoGTPases in murine secondary trophoblast cells. Dev Biol. 290:13-31.

15. El-Hashash, A, Esbrit, P and Kimber SJ (2005): PTHrP promotes murine secondary trophoblast differentiation through induction of endocycle, upregulation of giant-cell-promoting transcription factors and suppression of other trophoblast cell types. Differentiation. 73(4): 154-174. PMID: 15901283.

16. El-Hashash, A and Kimber SJ (2004): Trophoblast differentiation in vitro: establishment and characterisation of a serum-free culture model for murine secondary trophoblast giant cells. Reproduction.128(1): 53-71.



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