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Represeantative publications and corresponding author：
Vice Principal Global Access&Director, Global Health Academy&Professor of Medical and Veterinary Molecular Epidemiology, College of Medicine and Veterinary Medicine, The University of Edinburgh
Sue has a strong commitment to research focusing on interventions for disease control in the Global South, with on-going projects in Kenya, Morocco, Mozambique, Tanzania, Uganda, Nigeria, Zambia and Zanzibar. Her research has resulted in over 195 published works including 153 original research papers, 31 peer refereed reviews and 11 book chapters arising from >£30 million in research support.
Her publications have been cited over 6500 times and her h-index is 44. Sue has supervised 49 PhD and 4 MSc research students from Europe, the Americas, Africa and Asia, working on all aspects of Zoonotic disease management. Sue has a strong commitment to career development of young scientists. She was awarded the Chancellor’s Medal in 2011 by HRH The Princess Royal, Chancellor of The University of Edinburgh for her work on development of research-led distance learning MScs.
1. CD8 cells in immune regulation and development of autoimmune diseases： CD8+ regulatory T cells play key roles in maintaining self-tolerance. We have been focused on the study of Qa1-restricted CD8+ regulatory cells in mice. We have discovered that the suppressive activity of these regulatory cells was tightly regulated by the interaction of CD94/NKG2A and Qa1. Disruption of the CD94/NKG2A-Qa1 by either site-directed mutagenesis or antibody blockade enables the maximum release of NK and CD8+ suppressive activity and amelioration of autoimmune diseases such as EAE in mice（Lu et al. Immunity 2007, PNAS 2008）。We have recently reported that Glatiramer acetate, a FDA proved anti-MS drug, was able to induce Qa1-resricted CD8+ regulatory cells in mice, which could be used for the treatment of autoimmune IBD（Yao Y et al. Eur. J. Immunol. 2013）. We are currently exploring the role of CD8 subpopulations in anti-tumor and anti-viral responses. We are also interested in the equivalent subpopulation of CD8 regulatory cells in human and its relevance to human autoimmune and infectious diseases.
2. Thymocyte development and immune cell signaling：Programmed gene expression is critical for T-lineage cell differentiation as well as cell activation upon stimulation. We’ve analyzed the gene expression profile during thymocyte development in the thymus and identified an important adaptor protein Tespa1 (Wang et al. Nature Immunology 2012). Further analysis revealed that this molecule associates with TCR signaling components PLC-g1 and Grb2, and contributes to the activation of the Ca2+/NFAT pathways upon TCR engagement. We are currently investigating the molecular mechanisms how Tespa1 regulates TCR signaling as well as the role of some other important signaling molecules in regulating this development process.
3. Integrative signaling in Regulation of TH17 cell differentiation: TH17 cells (interleukin-17-producing helper T cells) are present at the sites of tissue inflam­mation and associated with the induction of multiple autoimmune diseases. The differentiation of TH17 cells is instructed and critically regulated by various cytokines in the microenvironment, which drive intracellular signaling process and transcription profiles that determine the cell fate. In our study, we found that MINK1, a germinal center kinase (GCK) family kinase, plays as a negative regulator for TH17 cell differentiation. We are currently investigating the mechanisms of this regulation.
Paper published in 5 years：
Liang J, Lyu J, Zhao M, Li D, Zheng M, Fang Y, Zhao F, Lou J, Guo C, Wang L, Wang D, Liu W* and Lu L*. Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors. Nature Communications (online)
Geng J, Yu S, Zhao H, Sun X, Li X, Wang P, Xiong X, Hong L, Xie C, Gao J, Shi Y, Peng J, Johnson RL, Xiao N, Lu L, Han J, Zhou D, Chen L. The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells. Nat Immunol. 2017 May 15. doi: 10.1038/ni.3748. [Epub ahead of print] (Pubmed)
Fu G, Xu Q, Qiu Y, Jin X, Xu T, Dong S, Wang J, Ke Y, Hu H, Cao X, Wang D, Cantor H, Gao X and Lu L*. Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1. J Exp Med. 2017 May 1;214(5):1453-1469. (Pubmed)
J Exp Med Insights： MINK1： The missing link between ROS and its inhibition of Th17 cells. Martinez GJ. J Exp Med. 2017 May 1;214(5):1205-1206. (LINK)
Zhang Y, Xu Y, Liu S, Guo X, Cen D, Xu J, Li H, Li K, Zeng C, Lu L, Zhou Y, Shen H, Cheng H, Zhang X, Ke Y*. Scaffolding protein Gab1 regulates myeloid dendritic cell migration in allergic asthma. Cell Res. 2016 Nov;26(11):1226-1241. (Pubmed)
Guo C, Xie S, Chi Z, Zhang J, Liu Y, Zhang L, Zheng M, Zhang X, Xia D, Ke Y, Lu L, Wang D*. Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. Immunity. 2016 Oct 18;45(4):802-816. (Pubmed)
Yue M, Luo D, Yu S, Liu P, Zhou Q, Hu M, Liu Y, Wang S, Huang Q, Niu Y, Lu L*, Hu H*. Misshapen/ NIK-related Kinase (MINK1) is involved in platelet function, hemostasis and thrombus formation. Blood. 2016 Feb 18;127(7):927-37. (Pubmed)
Yue Y, Huang W, Liang J, Guo J, Ji J, Yao Y, Zheng M, Cai Z, Lu L*, Wang J*. IL4I1 Is a Novel Regulator of M2 Macrophage Polarization That Can Inhibit T Cell Activation via L-Tryptophan and Arginine Depletion and IL-10 Production. PLoS One. 2015 Nov 24; 10(11):e0142979. doi: 10.1371/ journal.pone.0142979. eCollection 2015. (Pubmed)
Chen C, Li HQ, Liu YJ, Guo ZF, Wu HJ, Li X, Lou HF, Zhu L, Wang D, Li XM, Yu L, Cao X, Lu L, Gao Z, Duan SM*. A novel size-based sorting mechanism of pinocytic luminal cargoes in microglia. J Neurosci. 2015 Feb 11;35(6):2674-88. (Pubmed)
Wang D*, Zheng M, Qiu Y, Guo C, Ji J, Lei L, Zhang X, Liang J, Lou J, Huang W, Dong B, Wu S, Wang J, Ke Y, Cao X, Zhou YT and Lu L*, Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response. J Exp. Med. 2014 Dec 15;211(13):2635-49. (Pubmed)
Lu L* and Wang J*, One way to pathogenesis, many ways to homeostasis. Cellular & Molecular Immunology 2013 10:2-3. (Commentary) (Pubmed)
Yao Y, Han W, Liang J, Ji Jian, Wan J, Cantor H, Lu L*, Glatiramer acetate ameliorates inflammatory bowel disease in mice through the induction of Qa-1-restricted CD8+ regulatory cells. Eur. J. Immunol. 2013 Jan;43(1):125-36. (Pubmed)
Chen X, Yin Z, Chen JL, Shen WL, Liu HH, Tang QM, Fang Z, Lu LR, Ji J, Ouyang HW*. Force and scleraxis synergistically promote the commitment of human ES cells derived MSCs to tenocytes. Sci Rep. 2012;2:977. (Pubmed)
Wang X, Cui Y, Luo G, Wang Q, Hu J, He W, Yuan J, Zhou J, Wu Y, Sun X, Robson S, Li X, Tan J, Peng Y, Xue G，Lu L, Gao W, Wu J*. Activated mouse CD4+Foxp3− T cells facilitate melanoma metastasis via Qa-1-dependent suppression of NK-cell cytotoxicity. Cell Research. 2012 Dec; 22 (12): 1696-706. (Pubmed)
Wang D, Zheng M, Lei L, Ji J, Yao Y, Qiu Y, Ma L, Lou J, Ouyang C, Zhang X, He Y, Chi J, Wang L, Kuang Y, Wang J, Cao X and Lu L*, Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. Nature Immunology 13: 560–568 (2012). (Pubmed)
Nature Immunology News and Views: Tespa1: another gatekeeper for positive selection. by Nicholas R J Gascoigne & Guo Fu Nature Immunology 13,530–532(2012). (LINK)
Faculty 1000 Article Recommendation: New Finding, Interesting Hypothesis. (LINK)
Weng C, Dong H, Cheng G, Zhai Y, Bai R, Hu H, Lu L and Xu Z*, miR-409-3p inhibits HT1080 cell proliferation, vascularization and metastasis by targeting angiogenin. Cancer Lett. 2012 323(2): 171-179. (Pubmed)
Tenured Associate Professor ZJU-UoE Institute, ZJU 2017-Present
Tenure-track Associate Professor Tsinghua University 2010-2017
Postdoctoral fellow University of California, Los Angeles, CA, USA 2003-2010
EDUCATIONUniversity of Texas Graduate School of Biomedical Sciences, Houston, TX 1996-2002Ph. D., Molecular Genetics
Chinese Academy of Sciences Institute of Microbiology, Beijing, China 1992-1995M.S., Biochemistry
Nankai University, Tianjin, China 1988-1992B.S., Microbiology
HONORS AND AWARDSJassen-Tsinghua Investigator Award Jassen-Tsinghua University, Beijing, China 2011-2013
Bayer Investigator Award, Bayer-Tsinghua University, Beijing, China 2010
California Institute for Regenerative Medicine Training Grantthe California Institute for Regenerative Medicine & UCLA Institute for Stem Cell Biology andMedicine, California, USA 2006-2009
AACR-Merck Scholar-in-Training AwardAmerican Association of Cancer Research 100th Annual Meeting, Denver, CO, USA 2009
Boyer-Parvin Award and Best Postdoctoral Research Excellence Award University of California, Los Angeles, California, USA 2008
AACR-Bristol-Myers Squibb Oncology Scholar-in-Training AwardAmerican Association of Cancer Research 97th Annual Meeting, Washington DC, USA 2006
Keystone Symposia ScholarshipKeystone Hematopoiesis Symposium, Columbia British, Canada2001
Published Paper（*Correspongding Author, #the first author）：
a. Zhang Y, Xu W, Guo H, Zhang Y, He Y, Lee SH, Song X, Li X, Guo Y, Zhao Y, Ding C, Ning F, Ma Y, Lei QY, Hu X, Li S* and Guo W*. NOTCH1 signaling regulates self-renewal and platinum chemoresistance of cancer stem-like cells in human non-small cell lung cancer. Cancer Res 2017;77: 3082-91
b. Yang M, Chen S, Du J, He J, Wang Y, Li Z, Liu G, Peng W, Zeng X, Li D, Xu P, Guo W, Chang Z, Wang S, Tian Z, and Dong Z. NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation. Nature Communications 7, 12730 (2016)
c. Schubbert S, Cardenas A, Chen H, Garcia C, Guo W, Bradner JE, and Wu H. Targeting the MYC and PI3K pathways eliminates leukemia-initiating cells in T cell acute lymphoblastic leukemia. Cancer Res 2014;74:7048-59
d. Li Z, Lan Y, He W, Chen D, Wang J, Zhou F, Wang Y, Sun H, Chen X, Xu C, Li S, Zhu L, Fan M, Shang A, Ju Z, Luo L, Ding Y, Guo W, Cheng T, Yang X, and Liu B. Mouse Embryonic Head as a Novel Site for Hematopoietic Stem Cell Development. Cell Stem Cell 2012;11:663-75.
e. Guo W#, Schubbert S, Chen JY, Valamehr B, Mosessian S, Shi H, Dang NH, Garcia C, Theodoro MF, Varella-Garcia M, and Wu H. Suppression of leukemia development caused by PTEN loss. PNAS 2011; 108: 1409-1414.
f. Guo W#, Lasky JL, Chang CJ, Mosessian S, Lewis X, Xiao Y, Yeh JE, Chen JY, Iruela-Arispe LM, Varella-Garcia M, and Wu H. Multi-genetic events collaboratively contribute to Pten null leukemia stem cell formation. Nature 2008; 453: 529-533.
g. Drakos E., Rassidakis GZ, Leventaki V, Guo W, Medeiros LJ and Nagarajan L. Differential expression of the human MIXL1 gene product in Non-Hodgkin's and Hodgkin's lymphomas. Hum Pathol 2007; 38(3):500-7.
h. Guo W#, Liang H and Nagarajan L. Amino terminal tyrosine phosphorylation of human MIXL1. J. Mol. Signaling 2006; 1:6.
i. Yilmaz OH, Valdez R, Threisen BK, Guo W, Ferguson DO, Wu H, Morrison SJ. Pten dependence distinguishes hematopoietic stem cells from leukemia initiating cells. Nature 2006; 441:475-82.
j. Guo W* Lasky JL, and Wu H. Cancer stem cells. Pediatr Res 2006; 59: 59-64.
k. Stiles BL, Kuralwalla-Martinez C, Guo W, Gregorian C, Wang Y, Tian J, Magnuson MA, Wu H. Selective deletion of Pten in pancreatic β cells leads to increased islet mass and resistance to STZ-Induced diabetes. Mol Cell Biol 2006; 26:2772-81.
l. Guo W#, Chan AP, Liang H, Wieder ED, Molldrem JJ, Etkin LD and Nagarajan L. A human Mix-like homeobox gene MIXL shows functional similarity to Xenopus Mix.1. Blood 2002; 100:89-95.
m. Jiang Y, Liang H, Guo W, Kottickal LV and Nagarajan L. Differential expression of a novel C-terminally truncated splice form of SMAD5 in hematopoietic stem cells and leukemia. Blood 2000; 95(12): 3945-50.
n. Liang H, Guo W and Nagarajan L. Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277. Genomics 2000; 66(2): 226-8.
Edinburgh - Zhejiang Tenure Track Lecturer
Tenure Track Lecturer (Edinburgh/Zhejiang)
Personal Website: Edinburgh University
Dr Sander van den Driesche is a tenure track lecturer at the Zhejiang University - University of Edinburgh Institute and at the University of Edinburgh. Sander obtained his PhD degree at the Hubrecht Institute in the Netherlands, before moving to Edinburgh in 2006, where he joined the MRC Human Reproductive Sciences Unit as a post-doctoral researcher. In 2011 he became senior post-doc at the MRC Centre for Reproductive Health in Edinburgh. Since September 2016 he works for the ZJU/UoE Institute. His research focuses on the fetal origin of male reproductive health disorders and the regulation of the male programming window.
Dr Michael DawAcademic Track Lecturer ZJEEmail: Mdaw@staffmail.ed.ac.uk
Personal Website: Edinburgh University
Michael Daw is a lecturer based in the Centre for Discovery Brain Sciences. Work in the Daw lab studies the development of the electrical properties of neurons and synapses during early life. He has particular expertise in synaptic plasticity and inhibitory interneurons, defects in both of which are implicated in a number developmental disorders. Michael has most recently studied development in genetic models of intellectual disability and epilepsy.
Dr John Menzies
Email: firstname.lastname@example.orgPersonal Website: Edinburgh University
Undergraduate Programme Director, ZJELecturer, Centre for Discovery Brain Sciences, University of Edinburgh
Dr John Menzies is a lecturer at ZJE and the Centre for Discovery Brain Research at the University of Edinburgh. John is also the Programme Director for the undergraduate programmes at ZJE. Research in his laboratory focuses on the brain and its crucial role in eating behaviour. Unconscious neural systems constantly monitor the body’s energy status, and alert us to the availability of particularly energy-dense foods. Because of this, our body weight and food choices are under far less conscious control that we might think. John is interested in the neural correlates of appetite control and food reward, with a view to better understanding energy balance and so-called “food addiction”.
Dr Joanne Murray is an Academic Track Senior Lecturer (Zhejiang) and a Principal Investigator in the Centre for Discovery Brain Science, School of Biomedical Sciences. Joanne is a reproductive biologist with a particular interest in how nutrition can affect the reproductive axis. Three areas of current research are: 1. determining the role of hypothalamic melanin concentrating hormone expression in lactation; 2. characterizing the distribution of and interaction between the melanocortin receptors in the male and female reproductive axes; and 3. studying the role of oxygen in the growth and development of the ovarian follicle.
Melanie is a computational neurobiologist at the Centre for Discovery Brain Sciences at the University of Edinburgh. Her research group revolves around using computers to understand learning and memory across different scales: On a small scale, they simulate how molecules inside the brain work together to strengthen connections between neurons. On the large scale, they want to use data from digital educational tools to understand how students learn. Melanie’s background is in Mathematics and Biology, which she studied in her native Austria. She completed her PhD at the European Bioinformatics Institute in Cambridge (UK), and then went on to do post-doctoral work in Japan and the US. She joined the University of Edinburgh in 2015.
Professor Ahmed Hashash has completed his PhD from Manchester University, UK. He is a fellow of the California Institute of Regenerative Medicine (CIRM) and New York University Medical School (MSSM), USA. Prof. Ahmed Hashash worked as a senior biomedical research scientist at Mount Sinai School of Medicine of New York University and Children’s Hospital Los Angeles. He was Assistant Professor and Principal Investigator of Stem Cell & Regenerative Medicine at Keck School of Medicine and Ostrow School of Dentistry of The University of Southern California, USA. In 2016, Prof. Hashash has joined The University of Edinburgh, Edinburgh Medical School-Zhejiang International Campus, (ZJU) as Tenure-Track Associate Professor and Senior Principal Investigator of Biomedicine, Stem Cell & Regenerative Medicine. He is also adjunct Professor at the School of Basic Medical Science and School of Medicine, Zhejiang University. Prof. Hashash has several breakthrough discoveries in genes/enzymes that control stem cell behavior and regenerative medicine. He has published more than 25 papers in reputed international journals and serving as an editorial board member of repute. Prof. El-Hashash acts as a discussion leader at the prestigious Gordon Research Seminar/Conference in USA, and a Peer Reviewer/ International Extramural Review for The Medical Research Council (MRC) grant applications, London, UK. He is invited to speak at several international conferences in USA, Spain, Greece, Egypt and China. He is the editor or author of several books on stem cell and regenerative medicine.
Stem Cell, Regenerative Medicine, Biomedicine,
Stem Cell Therapy of Diseases & Cell and Developmental Biology
1.The functional role of transcription factors and protein phosphatases in both kidneyand lung development, repair and regeneration.
2.Molecular mechanisms involved in lung diseases such asthma, COPD and acute lung injury (ALI) and congenital lung abnormalities.
3.Identification of the genetic and molecular regulation of lung stem cell fate decisions and the balance between self-renewal and differentiation during normal development and during the disease process.
4.Analysis of molecular mechanisms that direct endogenous lung stem cells to generate any lung epithelial cell type, as a means for developing novel approaches to ameliorate human pulmonary disease.
Research Discovery Media Press Releases：
1. Berika M, Elgayyar M and El-Hashash A*. Asymmetric cell divisions of stem cells in the lung and other systems. Front Cell Dev Biol. (Stem Cell Treatments) 2014, 2:33. * Senior & Corresponding author
2. Lu K, Reddy R, Berika M, Warburton D, and El-Hashash A*. Abrogation of Six1/Eya1 disrupts the saccular phase of lung morphogenesis and cause remodeling. Dev Biol. 2013, 382: 110–123.* Senior & Corresponding author
3. El-Hashash A*, Turcatel G, Varma, S, Berika M, Alam D, and Warburton D. Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium. J Cell Sci. 2012, 125(Pt17): 4036-48. * Corresponding author
4. El-Hashash A* and Warburton D. Numb expression and asymmetric versus symmetric cell division in embryonic distal lung epithelium. J Histochem Cytochem. 2012, 60(9): 675-82. *Corresponding author
5. Turcatel G, Rubin N, El-Hashash AH and Warburton D. MIR-99a and MIR-99b modulate TGF-β induced epithelial to mesenchymal transition and regulate epithelial plasticity in murine mammary gland. Plos One 2012, 7(1):e31032.
6. El-Hashash A*, Turcatel G, Alam D, Buckley S, Bellusci S and Warburton D. Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development 2011,138(7): 1395-407. *Corresponding author
7. NieXu J, El-Hashash AH, Xu PX. Six1 regulates Grem1 expression in the meta-nephricmesenchyme to initiate branching morphogenesis. Dev Biol. 2011, 352(1):141-51.
8. El-Hashash A*, Alam D, Turcatel G, Bellusci S and Warburton D. Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the lung. Dev Biol. 2011, 353 (2): 242-258. *Corresponding author
9. El-Hashash A* , Warburton D. Cell polarity and spindle orientation in the distal epithelium of embryonic lung. Dev Dyn. 2011, 240(2):441-5. *Corresponding author
10. El-Hashash A, Alam D, Turcatel G, Bellusci S and Warburton D. Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol. 2010, 350(1):112-26.
11. Warburton D, El-Hashash A, Carraro G, Kemp P, Ricardi D, Bellusci S Shi W and Jesudason E (2010). Lung pattern formation, growth and development. Curr Top Dev Biol 90:73-158.
12. Carraro G, El-Hashash A, Guidolin D, Tiozzo C and Warburton D (2009). miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution. Dev Biol. 333(2): 238-50.
13. El-Hashash A, Warburton D and Kimber SJ (2009). Genes and signals regulating murine trophoblast cell development. Mech Dev. 127(1-2): 1-20.
14. El-Hashash, A and Kimber SJ (2006): PTHrP induces changes in cell cytoskeleton and E-cadherin, and regulates Eph/Ephrin kinases and RhoGTPases in murine secondary trophoblast cells. Dev Biol. 290:13-31.
15. El-Hashash, A, Esbrit, P and Kimber SJ (2005): PTHrP promotes murine secondary trophoblast differentiation through induction of endocycle, upregulation of giant-cell-promoting transcription factors and suppression of other trophoblast cell types. Differentiation. 73(4): 154-174. PMID: 15901283.
16. El-Hashash, A and Kimber SJ (2004): Trophoblast differentiation in vitro: establishment and characterisation of a serum-free culture model for murine secondary trophoblast giant cells. Reproduction.128(1): 53-71.
Ph.D Univsersity: The University of Edinburgh
1. Lu H, Talbot S, Robertson K A, et al. Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon- in primary macrophages requires endogenous 25-hydroxycholesterol synthesis[J]. Steroids, 2015, 99(Pt B):219-229.
2. Robertson K A, Hsieh W Y, Forster T, et al. An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway[J]. Plos Biology, 2016, 14(3):e1002364.
3. Lu H, Mazein A, Watterson S, et al. The Vitamin D3 Synthesis Pathway[J]. 2012.
Ph.D Univsersity: University of Auckland
Yao X, Bunt C, Cornish J, et al. Oral Delivery of Bovine Lactoferrin Using Pectin‐ and Chitosan‐Modified Liposomes and Solid Lipid Particles: Improvement of Stability of Lactoferrin[J]. Chemical Biology & Drug Design, 2015, 86(4):466.
Yao X, Bunt C, Cornish J, et al. Stability of Bovine Lactoferrin in Luminal Extracts and Mucosal Homogenates from Rat Intestine: A Prelude to Oral Absorption[J]. Chemical Biology & Drug Design, 2014, 84(6):676.
Yao X, Bunt C, Cornish J, et al. Preparation, optimization and characterization of bovine lactoferrin-loaded liposomes and solid lipid particles modified by hydrophilic polymers using factorial design.[J]. Chemical Biology & Drug Design, 2014, 83(5):560-575.
Yao X, Bunt C, Cornish J, et al. Oral Delivery of Lactoferrin: A Review[J]. International Journal of Peptide Research & Therapeutics, 2013, 19(2):125-134.
Yao X, Bunt C, Cornish J, et al. Improved RP‐HPLC method for determination of bovine lactoferrin and its proteolytic degradation in simulated gastrointestinal fluids[J]. Biomedical Chromatography Bmc, 2013, 27(2):197.
Wen J., Bunt C., Yao X. “Biodegradable Polymers: Applications in Particulate Delivery System”. Invited Book Chapter to Taylor and Francis Group. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Pages 715-731.
Ph.D Univsersity: Nanjing University of Science & Technology
Wei Wei, Yuxiao Li, Huazhe Yang, Reza Nassab, Fatemeh Shahriyari, Ali Akpek, Xiaofei Guan, Yanhui Liu, Shahrouz Taranejoo, Ali Tamayol, Yu Shrike Zhang, Ali Khademhosseini, Hae Lin Jang, 3D printed anchoring sutures for permanent shaping of tissues, Macromolecular Bioscience, 2017, 17, 1700304.
+Huazhe Yang, +Yuxiao Li, +Wei Wei, (+Co-first author), Fatemeh Sh, Ali Khademhosseini, Hae Lin Jang, Hydroxyapatite and Whitlockite bone nanocrystallite cocktails for delivering therapeutic ions to improve osteogenesis, (Under Preparation)
Wei Wei, Junjian Li, Xiaoliang Qi, Yin Zhong, Gancheng Zuo, Xihao Pan, Ting Su, Jianfa Zhang, Wei Dong, Synthesis and Characterization of a Multi-Sensitive Polysaccharide Hydrogel for Drug Delivery, Carbohydrate Polymers, 2017, 177, 275-283.
Wei Wei, Xiaoliang Qi, Junjian Li, Yin Zhong, Gancheng Zuo, Xihao Pan, Ting Su, Jianfa Zhang, Wei Dong. Synthesis and characterization of a novel cationic hydrogel base on salecan-g-PMAPTAC, International Journal of Biological Macromolecules, 2017, 101, 474-480.
Xiaoliang Qi, Wei Wei, Junjian Li, Gancheng Zuo, Xihao Pan, Ting Su, Jianfa Zhang, and Wei Dong, Salecan-based pH-sensitive hydrogels for insulin delivery, Molecular Pharmaceutics. 2017, 14, 431-440.
Xiaoliang Qi, Wei Wei, Junjian Li, Ting Su, Xihao Pan, Gancheng Zuo, Jianfa Zhang, Wei Dong. Design of Salecan-containing semi-IPN hydrogel for amoxicillin delivery, Materials Science and Engineering: C, 2017, 75, 487-494.
Xiaoliang Qi, Junjian Li, Wei Wei, Ting Su, Gancheng Zuo, Xihao Pan, Jianfa Zhang, and Wei Dong, Preparation of a Salecan/poly(2-acrylamido-2-methylpropanosulfonic acid-co-[2-(methacryloxy)ethyl]trimethylammonium chloride) Semi-IPN Hydrogel for Drug Delivery, ChemMedChem, 2017, 12: 1-11.
Xiaoliang Qi, Junjian Li, Wei Wei, Gancheng Zuo, Ting Su, Xihao Pan, Jianfa Zhang, Wei Dong. Cationic Salecan-based hydrogels for release of 5-fluorouracil, RSC Advances, 2017, 7, 14337-14347.
Junjian Li, Gancheng Zuo, Xiaoliang Qi, Wei Wei, Xihao Pan, Ting Su, Jianfa Zhang, Wei Dong, Selective determination of Ag+ using Salecan derived nitrogen doped carbon dots as a fluorescent probe, Materials Science and Engineering: C, 2017, 77, 508-512.
Wei Wei, Xiaoliang Qi, Gancheng Zuo, Junjian Li, Wei Sheng, Jianfa Zhang, Wei Dong, Smart Macroporous Salecan/Poly(N,N-diethylacrylamide) Semi-IPN Hydrogel for Anti-Inflammatory Drug Delivery, ACS Biomaterials Science & Engineering, 2016, 2: 1386-1394.
Junjian Li, Wei Wei, Xiaoliang Qi, Xiao Xu, Yucheng Liu, Qiuhan Lin, Wei Dong. Rational design, synthesis of reaction-based dual-channel cyanide sensor in aqueous solution, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2016, 152, 288-293.
Wei Sheng, Wei Wei, Junjian Li, Xiaoliang Qi, Gancheng Zuo, Qi Chen, Xihao Pan, and Wei Dong, Amine-Functionalized Magnetic Mesoporous Silica Nanoparticles for DNA Separation, Applied Surface Science, 2016, 387: 1116-1124.
Junjian Li, Wei Wei, Xiaoliang Qi, Gancheng Zuo, Jingkun Fang, Wei Dong. Highly selective colorimetric/fluorometric dual-channel sensor for cyanide based on ICT off in aqueous solution, Sensors and Actuators B: Chemical, 2016, 228, 330-334.
Xiaoliang Qi, Wei Wei, Junjian Li, Gancheng Zuo, Xinyu Hu, Jianfa Zhang, Wei Dong. Development of novel hydrogels based on Salecan and poly (N-isopropylacrylamide-co-methacrylic acid) for controlled doxorubicin release, RSC Advances, 2016, 6, 69869-69881.
Junjian Li, Xiaoliang Qi, Wei Wei, Gancheng Zuo, Wei Dong. A red-emitting fluorescent and colorimetric dual-channel sensor for cyanide based on a hybrid naphthopyran-benzothiazol in aqueous solution, Sensors and Actuators B: Chemical, 2016, 232, 666-672.
Yucheng Liu, Shufeng Li, Liandong Feng, Hao Yu, Xiaoliang Qi, Wei Wei, Junjian Li, and Wei Dong, Novel Disulfide-Containing Poly(b-amino ester)-Functionalised Magnetic Nanoparticles for Efficient Gene Delivery, Australian Journal of Chemistry, 2016, 69: 349-356.
Wei Wei, Xinyu Hu, Xiaoliang Qi, Hao Yu, Yucheng Liu, Junjian Li, Jianfa Zhang, Wei Dong. A novel thermo-responsive hydrogel based on salecan and poly(N-isopropylacrylamide): Synthesis and characterization, Colloids and Surfaces B: Biointerfaces, 2015, 125: 1-11.
Wei Wei, Xiaoliang Qi, Yucheng Liu, Junjian Li, Xinyu Hu, Gancheng Zuo, Jianfa Zhang, Wei Dong, Synthesis and characterization of a novel pH-thermo dual responsive hydrogel based on salecan and poly(N,N-diethylacrylamide-co-methacrylic acid), Colloids and Surfaces B: Biointerfaces, 2015, 136: 1182-1192.
Xinyu Hu, Wei Wei, Xiaoliang Qi, Hao Yu, Liandong Feng, Junjian Li, Shiming Wang, Jianfa Zhang, Wei Dong, Preparation and characterization of a novel pH-sensitive Salecan-g-poly (acrylic acid) hydrogel for controlled release of doxorubicin, Journal of Materials Chemistry B, 2015, 3: 2685-2697.
Xiaoliang Qi, Wei Wei, Junjian Li, Yucheng Liu, Xinyu Hu, Jianfa Zhang, Lirong Bi, and Wei Dong, Fabrication and Characterization of a Novel Anticancer Drug Delivery System: Salecan/Poly(methacrylic acid) Semi-interpenetrating Polymer Network Hydrogel, ACS Biomaterials Science & Engineering, 2015, 12: 1287-1299.
Junjian Li, Xiaoliang Qi, Wei Wei, Yucheng Liu, Xiao Xu, Qiuhan Lin, Wei Dong, A “donor-two-acceptor” sensor for cyanide detection in aqueous solution, Sensors and Actuators B: Chemical, 2015, 220: 986–991.
Xiaoliang Qi, Xinyu Hu, Wei Wei, Hao Yu, Junjian Li, Jianfa Zhang, Wei Dong, Investigation of Salecan/poly(vinyl alcohol) hydrogels prepared by freeze/thaw method, Carbohydrate Polymers, 2015, 118: 60-69.
Hao Yu, Shufeng Li, Liandong Feng, Yucheng Liu, Xiaoliang Qi, Wei Wei, Junjian Li, and Wei Dong, Diglycidyl Esters Cross-Linked with Low Molecular Weight Polyethyleneimine for Magnetofection, Australian Journal of Chemistry, 2015, 68: 1535-1542.
Xinyu Hu, Liandong Feng, Wei Wei, Aming Xie, Shiming Wang, Jianfa Zhang, Wei Dong, Synthesis and characterization of a novel semi-IPN hydrogel based on Salecan and poly(N,N-dimethylacrylamide-co-2-hydroxyethyl methacrylate), Carbohydrate Polymers, 2014, 105: 135-144.
Xinyu Hu, Liandong Feng, Aming Xie, Wei Wei, Shiming Wang, Jianfa Zhang, Wei Dong, Synthesis and characterization of a novel hydrogel: salecan/polyacrylamide semi-IPN hydrogel with a desirable pore structure, Journal of Materials Chemistry B, 2014, 2 (23): 3646-3658.