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Faculty

Professor

hwoy@zju.edu.cn

 

personal page 

 

 

 

 

Professional Memberships:

Committee Member, Tissue Engineering and Regenerative MedicineInternational Society–Asia Pacific
Alternate Chairman,Chinese Society of Biomedical Engineering (Tissue Engineering and Regenerative Medicine Section)
Editorial Board member, Biomaterials
Chairman, Chinese Association of Orthopaedic Surgeons, Chinese Orthopeadic Regenerative Medicine Sociery
Vice chairman, Chinese Association of Orthopaedic Surgeons Based committee
Director, Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine
Chairman, Zhejiang Provincial Biomedical Society
Final expert, FP-7 fund
External evaluation experts, BBSRC Research Grant Council in UK
External evaluation experts, Research Grants Council (RGC) of Hong Kong
Vice-editor, “Systematic Anatomy”, People's Medical Publishing House

 

 

  
科研项目:

1. 国家重点研发计划(重点专项),干细胞体外自动化、规模化培养基扩增体系,2017-2021,项目负责人
2. 国家自然科学基金(重点项目),退行性骨关节炎的亚型识别和再生研究,2017-2021,项目负责人
3. 国家重点研发计划(重点专项),材料基因工程关键技术与支撑平台-软骨诱导材料的高通量制备、高通量评价和临床试验,2016-2020,项目负责人
4. 国家自然科学基金(重点项目),SCX+NES+肌腱干细胞亚群分化的转录调控研究,2014-2018,项目负责人
5. 浙江省科学技术厅(重点科技创新团队),肌肉骨骼系统组织工程与再生医学技术创新团队,2014-2016,项目负责人
6. 国家高技术研究发展计划(863计划),组织再生关键实用技术和前瞻技术及产品研发,2012-2015,项目负责人 
7. 国家自然科学基金(杰出青年科学基金),运动医学,2012-2015,项目负责人

  

 

Represeantative publications and corresponding author:

      

Stem cell and sport medicine:
1.        Yin, Z; Hu, JJ; Yang, L; Zheng, ZF; An, CR; Wu, BB; Zhang, C; Shen, WL; Liu, HH; Chen, JL; Heng, BC; Guo, GJ; Chen, X; Ouyang, HW, Single-cell analysis reveals a nestin(+) tendon stem/progenitor cell population with strong tenogenic potentiality, SCIENCE ADVANCES, 2016;2(11), doi:e1600874,10.1126/sciadv.1600874 Science子刊
2.        Jun Dai, Dongsheng Yu, Yafei Wang, Yishan Chen, Heng Sun, Xiaolei Zhang, Shouan Zhu, Zongyou Pan, Boon Chin Heng, Shufang Zhang, Hongwei Ouyang, Kdm6b regulates cartilage development and homeostasis through anabolic metabolism. ANNALS OF THE RHEUMATIC DISEASES, 2016; 0:1-9, doi:10.1136/annrheumdis-2016-210407 IF:12.384
3.        Zhu, SA; Lu, P; Liu, HH; Chen, PF; Wu, Y; Wang, YY; Sun, H; Zhang, XL; Xia, QQ; Heng, BC; Zhou, YT; Ouyang, HW, Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo, ANNALS OF THE RHEUMATIC DISEASES, 2015;74(1):285-293, doi:10.1136/annrheumdis-2013-203901 被Nature Review Rheum highlight, 获得2013年软骨学会年度最优秀论文奖 IF:12.384
4.        Jiang, YZ; Cai, YZ; Zhang, W; Yin, Z; Hu, CC; Tong, T; Lu, P; Zhang, SF; Neculai, D; Tuan, RS; Ouyang, HW, Human Cartilage-Derived Progenitor Cells From Committed Chondrocytes for Efficient Cartilage Repair and Regeneration, STEM CELLS TRANSLATIONAL MEDICINE, 2016;5(6):733-744, doi:10.5966/sctm.2015-0192 STEM CELLS高亮引用并在2016年8月被国家基金委制作专门简报关节炎软骨修复与再生报送中央各部门。
5.        Hu, JJ; Yin, Z; Shen, WL; Xie, YB; Zhu, T; Lu, P; Cai, YZ; Kong, MJ; Heng, BC; Zhou, YT; Chen, WS; Chen, X; Ouyang, HW, Pharmacological Regulation of In Situ Tissue Stem Cells Differentiation for Soft Tissue Calcification Treatment, STEM CELLS, 2016
6.        Liu, HH; Zhang, C; Zhu, SA; Lu, P; Zhu, T; Gong, XN; Zhang, ZW; Hu, JJ; Yin, Z; Heng, BC; Chen, X; Ouyang, HW, Mohawk Promotes the Tenogenesis of Mesenchymal Stem Cells Through Activation of the TGF beta Signaling Pathway, STEM CELLS, 2015
7.        Yin, Z; Guo, J; Wu, TY; Chen, X; Xu, LL; Lin, SE; Sun, YX; Chan, KM; Ouyang, HW; Li, G,Stepwise Differentiation of Mesenchymal Stem Cells Augments Tendon-Like Tissue Formation and Defect Repair In Vivo, STEM CELLS TRANSLATIONAL MEDICINE, 2016
8.        Zhu, SA; Chen, PF; Wu, Y; Xiong, S; Sun, H; Xia, QQ; Shi, LB; Liu, HH; Ouyang, HW, Programmed Application of Transforming Growth Factor beta 3 and Rac1 Inhibitor NSC23766 Committed Hyaline Cartilage Differentiation of Adipose-Derived Stem Cells for Osteochondral Defect Repair, STEM CELLS TRANSLATIONAL MEDICINE, 2014
9.        Shen, WL; Chen, JL; Zhu, T; Chen, LK; Zhang, W; Fang, Z; Heng, BC; Yin, Z; Chen, X; Ji, JF; Chen, WS; Ouyang, HW, Intra-Articular Injection of Human Meniscus Stem/Progenitor Cells Promotes Meniscus Regeneration and Ameliorates Osteoarthritis Through Stromal Cell-Derived Factor-1/CXCR4-Mediated Homing, STEM CELLS TRANSLATIONAL MEDICINE, 2014
10.     Xia, QQ; Zhu, SA; Wu, Y; Wang, JQ; Cai, YZ; Chen, PF; Li, J; Heng, BC; Ouyang, HW; Lu, P, Intra-Articular Transplantation of Atsttrin-Transduced Mesenchymal Stem Cells Ameliorate Osteoarthritis Development, STEM CELLS TRANSLATIONAL MEDICINE, 2015
11.     Zhu, SA; Dai, J; Liu, HH; Cong, XX; Chen, YS; Wu, Y; Hu, H; Heng, BC; Ouyang, HW; Zhou, YT, Down-Regulation of Rac GTPase-Activating Protein OCRL1 Causes Aberrant Activation of Rac1 in Osteoarthritis Development, ARTHRITIS & RHEUMATOLOGY, 2015

 biomaterials and musculoskeletal tissue engineering:
1.        Wu, Y; Zhu, SA; Wu, CT; Lu, P; Hu, CC; Xiong, S; Chang, J; Heng, BC; Xiao, Y; Ouyang, HW, A Bi-Lineage Conducive Scaffold for Osteochondral Defect Regeneration, ADVANCED FUNCTIONAL MATERIALS, 2014;24(28): 4473-4483, doi:10.1016/j.biomaterials.2015.02.071, IF:11.382
2.        Yin, Z; Chen, X; Song, HX; Hu, JJ; Tang, QM; Zhu, T; Shen, WL; Chen, JL; Liu, HH; Heng, BC; Ouyang, HW, Electrospun scaffolds for multiple tissues regeneration in vivo through topography dependent induction of lineage specific differentiation, BIOMATERIALS, 2015; 44: 173-185, doi:10.1016/j.biomaterials.2015.04.060, Top ESI 1%
3.        Liu, HH; Peng, HJ; Wu, Y; Zhang, C; Cai, YZ; Xu, GW; Li, Q; Chen, X; Ji, JF; Zhang, YZ; OuYang, HW, The promotion of bone regeneration by nanofibrous hydroxyapatite/chitosan scaffolds by effects on integrin-BMP/Smad signaling pathway in BMSCs, BIOMATERIALS, 2013; 34(18):4404-4417, doi:10.1016/j.biomaterials.2015.02.051, Top ESI 1%
4.        Wang, JJ; Wang, JQ; Lu, P; Cai, YZ; Wang, YF; Hong, L; Ren, H; Heng, BC; Liu, H; Zhou, J; Ouyang, HW, Local delivery of FTY720 in PCL membrane improves SCI functional recovery by reducing reactive astrogliosis, BIOMATERIALS, 2015
5.        Chen, X; Gu, S; Chen, BF; Shen, WL; Yin, Z; Xu, GW; Hu, JJ; Zhu, T; Li, G; Wan, C; Ouyang, HW; Lee, TL; Chan, WY, Nanoparticle delivery of stable miR-199a-5p agomir improves the osteogenesis of human mesenchymal stem cells via the HIF1a pathway, BIOMATERIALS, 2015
6.        Zhang, C; Yuan, HH; Liu, HH; Chen, X; Lu, P; Zhu, T; Yang, L; Yin, Z; Heng, BC; Zhang, YZ; Ouyang, HW, Well-aligned chitosan-based ultrafine fibers committed teno-lineage differentiation of human induced pluripotent stem cells for Achilles tendon regeneration, BIOMATERIALS, 2015
7.        Chen, PF; Tao, JD; Zhu, SA; Cai, YZ; Mao, QJ; Yu, DS; Dai, J; Ouyang, HW, Radially oriented collagen scaffold with SDF-1 promotes osteochondral repair by facilitating cell homing, BIOMATERIALS, 2015
8.        Shen, WL; Chen, X; Hu, YJ; Yin, Z; Zhu, T; Hu, JJ; Chen, JL; Zheng, ZF; Zhang, W; Ran, JS; Heng, BC; Ji, JF; Chen, WS; Ouyang, HW, Long-term effects of knitted silk-collagen sponge scaffold on anterior cruciate ligament reconstruction and osteoarthritis prevention, BIOMATERIALS, 2014
9.        Ren, H; Han, M; Zhou, J; Zheng, ZF; Lu, P; Wang, JJ; Wang, JQ; Mao, QJ; Gao, JQ; Ouyang, HW, Repair of spinal cord injury by inhibition of astrocyte growth and inflammatory factor synthesis through local delivery of flavopiridol in PLGA nanoparticles, BIOMATERIALS, 2014
10.     Chen, PF; Zhu, SA; Wang, YY; Mu, Q; Wu, Y; Xia, QQ; Zhang, XL; Sun, H; Tao, JD; Hu, H; Lu, P; Ouyang, HW, The amelioration of cartilage degeneration by ADAMTS-5 inhibitor delivered in a hyaluronic acid hydrogel, BIOMATERIALS, 2014
11.     Shi, LB; Cai, HX; Chen, LK; Wu, Y; Zhu, SA; Gong, XN; Xia, YX; Ouyang, HW; Zou, XH, Tissue engineered bulking agent with adipose-derived stem cells and silk fibroin microspheres for the treatment of intrinsic urethral sphincter deficiency, BIOMATERIALS, 2014
12.     Zhang, W; Chen, JL; Tao, JD; Hu, CC; Chen, LK; Zhao, HS; Xu, GW; Heng, BC; Ouyang, HW, The promotion of osteochondral repair by combined intra-articular injection of parathyroid hormone-related protein and implantation of a bi-layer collagen-silk scaffold, BIOMATERIALS, 2013
13.     Zhang, W; Chen, JL; Tao, JD; Jiang, YZ; Hu, CC; Huang, L; Ji, JF; Ouyang, HW, The use of type 1 collagen scaffold containing stromal cell-derived factor-1 to create a matrix environment conducive to partial-thickness cartilage defects repair, BIOMATERIALS, 2013
14.     Wang, W; Li, B; Yang, JZ; Xin, L; Li, YL; Yin, HP; Qi, YY; Jiang, YZ; Ouyang, HW; Gao, CY, The restoration of full-thickness cartilage defects with BMSCs and TGF-beta 1 loaded PLGA/fibrin gel constructs, BIOMATERIALS, 2010
15.     Chen, JL; Yin, Z; Shen, WLA; Chen, XA; Heng, BC; Zou, XAH; Ouyang, HW, Efficacy of hESC-MSCs in knitted silk-collagen scaffold for tendon tissue engineering and their roles, BIOMATERIALS, 2010
16.     Shen, WL; Chen, XA; Chen, JL; Yin, Z; Heng, BC; Chen, WS; Ouyang, HW, The effect of incorporation of exogenous stromal cell-derived factor-1 alpha within a knitted silk-collagen sponge scaffold on tendon regeneration, BIOMATERIALS, 2010
17.     Wang, W; Li, B; Li, YL; Jiang, YZ; Ouyang, HW; Gao, CY, In vivo restoration of full-thickness cartilage defects by poly(lactide-co-glycolide) sponges filled with fibrin gel, bone marrow mesenchymal stem cells and DNA complexes, BIOMATERIALS, 2010
18.     Zou, XH; Zhi, YL; Chen, X; Jin, HM; Wang, LL; Jiang, YZ; Yin, Z; Ouyang, HW, Mesenchymal stem cell seeded knitted silk sling for the treatment of stress urinary incontinence, BIOMATERIALS, 2010
19.     Yin, Z; Chen, X; Chen, JL; Shen, WL; Nguyen, TMH; Gao, L; Ouyang, HW, The regulation of tendon stem cell differentiation by the alignment of nanofibers, BIOMATERIALS, 2010
20.     Chen, X; Qi, YY; Wang, LL; Yin, Z; Yin, GL; Zou, XH; Ouyang, HW, Ligament regeneration using a knitted silk scaffold combined with collagen matrix, BIOMATERIALS, 2008
21.     Wu, YN; Yang, Z; Hui, JHP; Ouyang, HW; Lee, EH, Cartilaginous ECM component-modification of the micro-bead culture system for chondrogenic differentiation of mesenchymal stem cells, BIOMATERIALS, 2007

  

Professor

Email: sue.welburn@ed.ac.uk





Vice Principal Global Access&Director, Global Health Academy&Professor of Medical and Veterinary
Molecular Epidemiology, College of Medicine and Veterinary Medicine, The University of Edinburgh


Sue has a strong commitment to research focusing on interventions for disease control in the Global South, with on-going projects in Kenya, Morocco, Mozambique, Tanzania, Uganda, Nigeria, Zambia and Zanzibar. Her research has resulted in over 195 published works including 153 original research papers, 31 peer refereed reviews and 11 book chapters arising from >£30 million in research support.

Her publications have been cited over 6500 times and her h-index is 44.  Sue has supervised 49 PhD and 4 MSc research students from Europe, the Americas, Africa and Asia, working on all aspects of Zoonotic disease management. Sue has a strong commitment to career development of young scientists. She was awarded the Chancellor’s Medal in 2011 by HRH The Princess Royal, Chancellor of The University of Edinburgh for her work on development of research-led distance learning MScs.

 

Professor

lu_linrong@zju.edu.cn

Personal Page

 

 

 

 

 

On-going Projects:

 

1. CD8 cells in immune regulation and development of autoimmune diseases: CD8+ regulatory T cells play key roles in maintaining self-tolerance. We have been focused on the study of Qa1-restricted CD8+ regulatory cells in mice. We have discovered that the suppressive activity of these regulatory cells was tightly regulated by the interaction of CD94/NKG2A and Qa1. Disruption of the CD94/NKG2A-Qa1 by either site-directed mutagenesis or antibody blockade enables the maximum release of NK and CD8+ suppressive activity and amelioration of autoimmune diseases such as EAE in mice(Lu et al. Immunity 2007, PNAS 2008)。We have recently reported that Glatiramer acetate, a FDA proved anti-MS drug, was able to induce Qa1-resricted CD8+ regulatory cells in mice, which could be used for the treatment of autoimmune IBD(Yao Y et al. Eur. J. Immunol. 2013). We are currently exploring the role of CD8 subpopulations in anti-tumor and anti-viral responses. We are also interested in the equivalent subpopulation of CD8 regulatory cells in human and its relevance to human autoimmune and infectious diseases.

2. Thymocyte development and immune cell signaling:Programmed gene expression is critical for T-lineage cell differentiation as well as cell activation upon stimulation. We’ve analyzed the gene expression profile during thymocyte development in the thymus and identified an important adaptor protein Tespa1 (Wang et al. Nature Immunology 2012). Further analysis revealed that this molecule associates with TCR signaling components PLC-g1 and Grb2, and contributes to the activation of the Ca2+/NFAT pathways upon TCR engagement. We are currently investigating the molecular mechanisms how Tespa1 regulates TCR signaling as well as the role of some other important signaling molecules in regulating this development process.

3. Integrative signaling in Regulation of TH17 cell differentiation: TH17 cells (interleukin-17-producing helper T cells) are present at the sites of tissue inflam­mation and associated with the induction of multiple autoimmune diseases. The differentiation of TH17 cells is instructed and critically regulated by various cytokines in the microenvironment, which drive intracellular signaling process and transcription profiles that determine the cell fate. In our study, we found that MINK1, a germinal center kinase (GCK) family kinase, plays as a negative regulator for TH17 cell differentiation. We are currently investigating the mechanisms of this regulation.

 

Paper published in 5 years:

2017

Liang J, Lyu J, Zhao M, Li D, Zheng M, Fang Y, Zhao F, Lou J, Guo C, Wang L, Wang D, Liu W* and Lu L*. Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors. Nature Communications (online)

Geng J, Yu S, Zhao H, Sun X, Li X, Wang P, Xiong X, Hong L, Xie C, Gao J, Shi Y, Peng J, Johnson RL, Xiao N, Lu L, Han J, Zhou D, Chen L. The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells. Nat Immunol. 2017 May 15. doi: 10.1038/ni.3748. [Epub ahead of print] (Pubmed)

Fu G, Xu Q, Qiu Y, Jin X, Xu T, Dong S, Wang J, Ke Y, Hu H, Cao X, Wang D, Cantor H, Gao X and Lu L*. Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1. J Exp Med. 2017 May 1;214(5):1453-1469. (Pubmed)

J Exp Med Insights: MINK1: The missing link between ROS and its inhibition of Th17 cells. Martinez GJ. J Exp Med. 2017 May 1;214(5):1205-1206. (LINK)

 

2016

Zhang Y, Xu Y, Liu S, Guo X, Cen D, Xu J, Li H, Li K, Zeng C, Lu L, Zhou Y, Shen H, Cheng H, Zhang X, Ke Y*. Scaffolding protein Gab1 regulates myeloid dendritic cell migration in allergic asthma. Cell Res. 2016 Nov;26(11):1226-1241. (Pubmed)

Guo C, Xie S, Chi Z, Zhang J, Liu Y, Zhang L, Zheng M, Zhang X, Xia D, Ke Y, Lu L, Wang D*. Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. Immunity. 2016 Oct 18;45(4):802-816. (Pubmed)

Yue M, Luo D, Yu S, Liu P, Zhou Q, Hu M, Liu Y, Wang S, Huang Q, Niu Y, Lu L*, Hu H*. Misshapen/ NIK-related Kinase (MINK1) is involved in platelet function, hemostasis and thrombus formation. Blood. 2016 Feb 18;127(7):927-37. (Pubmed)

 

2015

Yue Y, Huang W, Liang J, Guo J, Ji J, Yao Y, Zheng M, Cai Z, Lu L*, Wang J*. IL4I1 Is a Novel Regulator of M2 Macrophage Polarization That Can Inhibit T Cell Activation via L-Tryptophan and Arginine Depletion and IL-10 Production. PLoS One. 2015 Nov 24; 10(11):e0142979. doi: 10.1371/ journal.pone.0142979. eCollection 2015. (Pubmed)

Chen C, Li HQ, Liu YJ, Guo ZF, Wu HJ, Li X, Lou HF, Zhu L, Wang D, Li XM, Yu L, Cao X, Lu L, Gao Z, Duan SM*. A novel size-based sorting mechanism of pinocytic luminal cargoes in microglia.  J Neurosci. 2015 Feb 11;35(6):2674-88. (Pubmed)

 

2014

Wang D*, Zheng M, Qiu Y, Guo C, Ji J, Lei L, Zhang X, Liang J, Lou J, Huang W, Dong B, Wu S, Wang J, Ke Y, Cao X, Zhou YT and Lu L*, Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response. J Exp. Med. 2014 Dec 15;211(13):2635-49. (Pubmed)

 

2013

Lu L* and Wang J*, One way to pathogenesis, many ways to homeostasis. Cellular & Molecular Immunology 2013 10:2-3. (Commentary) (Pubmed)

Yao Y, Han W, Liang J, Ji Jian, Wan J, Cantor H, Lu L*, Glatiramer acetate ameliorates inflammatory bowel disease in mice through the induction of Qa-1-restricted CD8+ regulatory cells. Eur. J. Immunol. 2013 Jan;43(1):125-36. (Pubmed)

 

2012

Chen X, Yin Z, Chen JL, Shen WL, Liu HH, Tang QM, Fang Z, Lu LR, Ji J, Ouyang HW*. Force and scleraxis synergistically promote the commitment of human ES cells derived MSCs to tenocytes. Sci Rep. 2012;2:977. (Pubmed)

Wang X, Cui Y, Luo G, Wang Q, Hu J, He W, Yuan J, Zhou J, Wu Y, Sun X, Robson S, Li X, Tan J, Peng Y, Xue G,Lu L, Gao W, Wu J*. Activated mouse CD4+Foxp3− T cells facilitate melanoma metastasis via Qa-1-dependent suppression of NK-cell cytotoxicity.  Cell Research. 2012 Dec; 22 (12): 1696-706. (Pubmed)

Wang D, Zheng M, Lei L, Ji J, Yao Y, Qiu Y, Ma L, Lou J, Ouyang C, Zhang X, He Y, Chi J, Wang L, Kuang Y, Wang J, Cao X and Lu L*, Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. Nature Immunology 13: 560–568 (2012). (Pubmed)

Nature Immunology News and Views: Tespa1: another gatekeeper for positive selection. by Nicholas R J Gascoigne & Guo Fu Nature Immunology 13,530–532(2012). (LINK)

Faculty 1000 Article Recommendation: New Finding, Interesting Hypothesis. (LINK)

Weng C, Dong H, Cheng G, Zhai Y, Bai R, Hu H, Lu L and Xu Z*, miR-409-3p inhibits HT1080 cell proliferation, vascularization and metastasis by targeting angiogenin. Cancer Lett. 2012 323(2): 171-179. (Pubmed)

 

 

Associate Professor

weiguo_job@outlook.com

weiguo@intl.zju.edu.cn




PROFESSION

Tenured Associate Professor              ZJU-UoE Institute, ZJU                                2017-Present

Tenure-track Associate Professor       Tsinghua University                                          2010-2017

Postdoctoral fellow University of California, Los Angeles, CA, USA                             2003-2010

EDUCATION
University of Texas Graduate School of Biomedical Sciences, Houston, TX               1996-2002
Ph. D., Molecular Genetics

Chinese Academy of Sciences Institute of Microbiology, Beijing, China                      1992-1995
M.S., Biochemistry

Nankai University, Tianjin, China                                                                                  1988-1992
B.S., Microbiology

HONORS AND AWARDS
Jassen-Tsinghua Investigator Award                
Jassen-Tsinghua University, Beijing, China                                                                  2011-2013

Bayer Investigator Award,
Bayer-Tsinghua University, Beijing, China                                                                             2010

California Institute for Regenerative Medicine Training Grant
the California Institute for Regenerative Medicine & UCLA Institute for Stem Cell Biology and
Medicine, California, USA                                                                                             2006-2009

AACR-Merck Scholar-in-Training Award
American Association of Cancer Research 100th Annual Meeting, Denver, CO, USA         2009

Boyer-Parvin Award and Best Postdoctoral Research Excellence Award
University of California, Los Angeles, California, USA                                                           2008

AACR-Bristol-Myers Squibb Oncology Scholar-in-Training Award
American Association of Cancer Research 97th Annual Meeting, Washington DC, USA     2006

Keystone Symposia Scholarship
Keystone Hematopoiesis Symposium, Columbia British, Canada
2001


 
Published Paper(*Correspongding Author, #the first author):

a. Zhang Y, Xu W, Guo H, Zhang Y, He Y, Lee SH, Song X, Li X, Guo Y, Zhao Y, Ding C, Ning F, Ma Y, Lei QY, Hu X, Li S* and Guo W*. NOTCH1 signaling regulates self-renewal and platinum chemoresistance of cancer stem-like cells in human non-small cell lung cancer. Cancer Res 2017;77: 3082-91

b. Yang M, Chen S, Du J, He J, Wang Y, Li Z, Liu G, Peng W, Zeng X, Li D, Xu P, Guo W, Chang Z, Wang S, Tian Z, and Dong Z. NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation. Nature Communications 7, 12730 (2016)

c. Schubbert S, Cardenas A, Chen H, Garcia C, Guo W, Bradner JE, and Wu H. Targeting the MYC and PI3K pathways eliminates leukemia-initiating cells in T cell acute lymphoblastic leukemia. Cancer Res 2014;74:7048-59

d. Li Z, Lan Y, He W, Chen D, Wang J, Zhou F, Wang Y, Sun H, Chen X, Xu C, Li S, Zhu L, Fan M, Shang A, Ju Z, Luo L, Ding Y, Guo W, Cheng T, Yang X, and Liu B. Mouse Embryonic Head as a Novel Site for Hematopoietic Stem Cell Development. Cell Stem Cell 2012;11:663-75.

e. Guo W#, Schubbert S, Chen JY, Valamehr B, Mosessian S, Shi H, Dang NH, Garcia C, Theodoro MF, Varella-Garcia M, and Wu H. Suppression of leukemia development caused by PTEN loss. PNAS 2011; 108: 1409-1414.

f. Guo W#, Lasky JL, Chang CJ, Mosessian S, Lewis X, Xiao Y, Yeh JE, Chen JY, Iruela-Arispe LM, Varella-Garcia M, and Wu H. Multi-genetic events collaboratively contribute to Pten null leukemia stem cell formation. Nature 2008; 453: 529-533.

g. Drakos E., Rassidakis GZ, Leventaki V, Guo W, Medeiros LJ and Nagarajan L. Differential expression of the human MIXL1 gene product in Non-Hodgkin's and Hodgkin's lymphomas. Hum Pathol 2007; 38(3):500-7.

h. Guo W#, Liang H and Nagarajan L. Amino terminal tyrosine phosphorylation of human MIXL1. J. Mol. Signaling 2006; 1:6.

i. Yilmaz OH, Valdez R, Threisen BK, Guo W, Ferguson DO, Wu H, Morrison SJ. Pten dependence distinguishes hematopoietic stem cells from leukemia initiating cells. Nature 2006; 441:475-82.

j. Guo W* Lasky JL, and Wu H. Cancer stem cells. Pediatr Res 2006; 59: 59-64.

k. Stiles BL, Kuralwalla-Martinez C, Guo W, Gregorian C, Wang Y, Tian J, Magnuson MA, Wu H. Selective deletion of Pten in pancreatic β cells leads to increased islet mass and resistance to STZ-Induced diabetes. Mol Cell Biol 2006; 26:2772-81.

l. Guo W#, Chan AP, Liang H, Wieder ED, Molldrem JJ, Etkin LD and Nagarajan L. A human Mix-like homeobox gene MIXL shows functional similarity to Xenopus Mix.1. Blood 2002; 100:89-95.

m. Jiang Y, Liang H, Guo W, Kottickal LV and Nagarajan L. Differential expression of a novel C-terminally truncated splice form of SMAD5 in hematopoietic stem cells and leukemia. Blood 2000; 95(12): 3945-50.

n. Liang H, Guo W and Nagarajan L. Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277. Genomics 2000; 66(2): 226-8.
 
 


 


Adjunct Professor

yke@zju.edu.cn

 Personal Website 


Edinburgh - Zhejiang Tenure Track Lecturer

email:nicola.romano@ed.ac.uk

Personal Page




Adjunct Professor

zhouyt@zju.edu.cn

  Personal Website    

Tenure Track Lecturer (Edinburgh/Zhejiang)

Email: S.vandenDriesche@ed.ac.uk

Personal Website: Edinburgh University




Dr Sander van den Driesche is a tenure track lecturer at the Zhejiang University - University of Edinburgh Institute and at the University of Edinburgh. Sander obtained his PhD degree at the Hubrecht Institute in the Netherlands, before moving to Edinburgh in 2006, where he joined the MRC Human Reproductive Sciences Unit as a post-doctoral researcher. In 2011 he became senior post-doc at the MRC Centre for Reproductive Health in Edinburgh. Since September 2016 he works for the ZJU/UoE Institute. His research focuses on the fetal origin of male reproductive health disorders and the regulation of the male programming window.



Adjunct Professor

xhyang@zju.edu.cn

  Personal Website   


Dr Michael Daw
Academic Track Lecturer ZJE


Michael Daw is a lecturer based in the Centre for Discovery Brain Sciences. Work in the Daw lab studies the development of the electrical properties of neurons and synapses during early life. He has particular expertise in synaptic plasticity and inhibitory interneurons, defects in both of which are implicated in a number developmental disorders. Michael has most recently studied development in genetic models of intellectual disability and epilepsy.


Email: Mdaw@staffmail.ed.ac.uk

Personal Website: Edinburgh University



Adjunct Professor

yudongzhou@zju.edu.cn

  Personal Website   



Adjunct Professor

jingweizhao@zju.edu.cn

 Personal Website 

Dr John Menzies
Undergraduate Programme Director, ZJE
Lecturer, Centre for Discovery Brain Sciences, University of Edinburgh


Dr John Menzies is a lecturer at ZJE and the Centre for Discovery Brain Research at the University of Edinburgh. John is also the Programme Director for the undergraduate programmes at ZJE. Research in his laboratory focuses on the brain and its crucial role in eating behaviour. Unconscious neural systems constantly monitor the body’s energy status, and alert us to the availability of particularly energy-dense foods. Because of this, our body weight and food choices are under far less conscious control that we might think. John is interested in the neural correlates of appetite control and food reward, with a view to better understanding energy balance and so-called “food addiction”.


Email: john.menzies@ed.ac.uk
Personal Website: Edinburgh University



Adjunct Professor

jmurra19@exseed.ed.ac.uk

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Adjunct Professor

huhu@zju.edu.cn

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Adjunct Professor

Email:rsloan2@ed.ac.uk


 Personal Page 


Adjunct Professor

wanglie@zju.edu.cn

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Adjunct Professor

diwang@zju.edu.cn

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Adjunct Professor

mstefan@exseed.ed.ac.uk

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Adjunct Professor

stijnvanderveen@zju.edu.cn




Associate Professor

aelhashash@hotmail.com






Biography:

Professor Ahmed Hashash has completed his PhD from Manchester University, UK. He is a fellow of the California Institute of Regenerative Medicine (CIRM) and New York University Medical School (MSSM), USA. Prof. Ahmed Hashash worked as a senior biomedical research scientist at Mount Sinai School of Medicine of New York University and Children’s Hospital Los Angeles. He was Assistant Professor and Principal Investigator of Stem Cell & Regenerative Medicine at Keck School of Medicine and Ostrow School of Dentistry of The University of Southern California, USA. In 2016, Prof. Hashash has joined The University of Edinburgh, Edinburgh Medical School-Zhejiang International Campus, (ZJU) as Tenure-Track Associate Professor and Senior Principal Investigator of Biomedicine, Stem Cell & Regenerative Medicine. He is also adjunct Professor at the School of Basic Medical Science and School of Medicine, Zhejiang University. Prof. Hashash has several breakthrough discoveries in genes/enzymes that control stem cell behavior and regenerative medicine. He has published more than 25 papers in reputed international journals and serving as an editorial board member of repute. Prof. El-Hashash acts as a discussion leader at the prestigious Gordon Research Seminar/Conference in USA, and a Peer Reviewer/ International Extramural Review for The Medical Research Council (MRC) grant applications, London, UK. He is invited to speak at several international conferences in USA, Spain, Greece, Egypt and China. He is the editor or author of several books on stem cell and regenerative medicine.


Research Interests:

Stem Cell, Regenerative Medicine, Biomedicine, 

Stem Cell Therapy of Diseases  & Cell and Developmental Biology


Research Topics:

1.The functional role of transcription factors and protein phosphatases in both kidneyand lung development, repair and regeneration.

2.Molecular mechanisms involved in lung diseases such asthma, COPD and acute lung injury (ALI) and congenital lung abnormalities.

3.Identification of the genetic and molecular regulation of lung stem cell fate decisions and the balance between self-renewal and differentiation during normal development and during the disease process.

4.Analysis of molecular mechanisms that direct endogenous lung stem cells to generate any lung epithelial cell type, as a means for developing novel approaches to ameliorate human pulmonary disease.


Research Discovery Media Press Releases:

-http://www.chla.org/press-release/researchers-children-s-hospital-los-angeles-identify-key-aspect-lung-epithelial

-http://respiratory-care-sleep-medicine.advanceweb.com/News/Industry-News/Mechanism-Critical-to-Lung-Formation-and-Regeneration-Identified.aspx

-http://www.news-medical.net/news/20120703/Scientists-discover-Eya1-enzyme-control-of-pulmonary-barrier-integrity.aspx

-http://www.chla.org/press-release/investigators-the-saban-research-institute-children-s-hospital-los-angeles-discover

-http://news.usc.edu/30958/Essential-Enzyme-for-Healthy-Lung-Development-Discovered/

-https://www.eurekalert.org/pub_releases/2011-03/chla-ide032911.php

-https://medicalxpress.com/news/2011-03-enzyme-essential-healthy-lung.html

AHMEND MEDIA.png

Selected Publications:

1. Berika M, Elgayyar M and El-Hashash A*. Asymmetric cell divisions of stem cells in the lung and other systems. Front Cell Dev Biol. (Stem Cell Treatments) 2014, 2:33. * Senior & Corresponding author

2. Lu K, Reddy R, Berika M, Warburton D, and El-Hashash A*. Abrogation of Six1/Eya1 disrupts the saccular phase of lung morphogenesis and cause remodeling. Dev Biol. 2013, 382: 110–123.* Senior & Corresponding author

3. El-Hashash A*, Turcatel G, Varma, S, Berika M, Alam D, and Warburton D. Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium. J Cell Sci. 2012, 125(Pt17): 4036-48. * Corresponding author

4. El-Hashash A* and Warburton D. Numb expression and asymmetric versus symmetric cell division in embryonic distal lung epithelium. J Histochem Cytochem. 2012, 60(9): 675-82. *Corresponding author

5. Turcatel G, Rubin N, El-Hashash AH and Warburton D. MIR-99a and MIR-99b modulate TGF-β induced epithelial to mesenchymal transition and regulate epithelial plasticity in murine mammary gland. Plos One 2012, 7(1):e31032.

6. El-Hashash A*, Turcatel G, Alam D, Buckley S, Bellusci S and Warburton D. Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development 2011,138(7): 1395-407. *Corresponding author

7. NieXu J, El-Hashash AH, Xu PX. Six1 regulates Grem1 expression in the meta-nephricmesenchyme to initiate branching morphogenesis. Dev Biol. 2011, 352(1):141-51.

8. El-Hashash A*, Alam D, Turcatel G, Bellusci S and Warburton D. Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the lung. Dev Biol. 2011, 353 (2): 242-258. *Corresponding author

9. El-Hashash A* , Warburton D. Cell polarity and spindle orientation in the distal epithelium of embryonic lung. Dev Dyn. 2011, 240(2):441-5. *Corresponding author

10. El-Hashash A, Alam D, Turcatel G, Bellusci S and Warburton D. Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol. 2010, 350(1):112-26.

11. Warburton D, El-Hashash A, Carraro G, Kemp P, Ricardi D, Bellusci S Shi W and Jesudason E (2010). Lung pattern formation, growth and development. Curr Top Dev Biol 90:73-158.

12. Carraro G, El-Hashash A, Guidolin D, Tiozzo C and Warburton D (2009). miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution. Dev Biol. 333(2): 238-50.

13. El-Hashash A, Warburton D and Kimber SJ (2009). Genes and signals regulating murine trophoblast cell development. Mech Dev. 127(1-2): 1-20.

14. El-Hashash, A and Kimber SJ (2006): PTHrP induces changes in cell cytoskeleton and E-cadherin, and regulates Eph/Ephrin kinases and RhoGTPases in murine secondary trophoblast cells. Dev Biol. 290:13-31.

15. El-Hashash, A, Esbrit, P and Kimber SJ (2005): PTHrP promotes murine secondary trophoblast differentiation through induction of endocycle, upregulation of giant-cell-promoting transcription factors and suppression of other trophoblast cell types. Differentiation. 73(4): 154-174. PMID: 15901283.

16. El-Hashash, A and Kimber SJ (2004): Trophoblast differentiation in vitro: establishment and characterisation of a serum-free culture model for murine secondary trophoblast giant cells. Reproduction.128(1): 53-71.