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The neural circuitry mechanism for olfactory cue-induced innate fear in mice

01/05/2016

Research by collaboration of Prof. Shumin Duan and Hao Wang from institution of neuroscience, basic medical school discovered new circuit mechanisms for innate fear. This study is published online on Jan 4th, 2016 at Nature Neuroscience.

Innate fear plays a critical role in survival and heath for all species, including human being. This intense emotion induced by a perceived threat through sensory stimuli is vital for animals to avoid danger, thus could survive. On the other hand, abnormal fear such as phobia is highly associated with anxiety and depression disorders. The features of heritability and natural acquisition distinguish innate fear from conditioned fear. The former is innate while the latter requires previous experiences. Unlike conditioned fear, the neuronal circuitry underlying innate fear is largely unknown. The team leaded by Shumin Duan and Hao Wang employed optogenetics, behavioral assays and retrograde rabies virus tracing techniques, and found that projection from the lateral habenula to the laterodorsal tegmentum played a key role in the olfactory cue-induced innate fear in mice. Furthermore, they found two interneuron subtypes (PV+ and SOM+) antagonistically regulated fear responses. These results provided a potential target for therapeutic intervention for anxiety and depression disorders.

Drs. Hongbin Yang and Junhua Yang are co-first authors of this paper. This study was supported by grants from the Major State Basic Research Program of China and the National Natural Science Foundation of China