主题: Histone phosphorylation recruits topoisomerase IIα to centromeres to safeguard genomic stability
主讲人: Mike Ludwig教授
The brain uses more than 100 different peptides as chemical signals to communicate information, and these have a role in information processing that is quite unlike that of conventional neurotransmitters. Neuropeptides are released from all parts of a neuron, including the axon, soma and, especially, the dendrites, and so are not restricted spatially by synaptic wiring. The neuropeptides oxytocin and vasopressin, are released from dendrites in response to diverse physiological stimuli and dendritic release can be regulated independently from axon terminal release. Oxytocin and vasopressin function as autocrine or paracrine signals at their site of origin, but can also act at distant brain targets to evoke long-lasting changes in behaviour. Thus, diffuse spread of neuropeptides in the extracellular fluid following dendritic release, in addition with focal release from axonal terminals, contributes to regionally and temporally varying combinations of actions providing a large diversity in interneuronal signalling.