Title: Why redhaired individuals are so prone to developing melanoma?
Speakers: Prof. Rutao Cui
Qiushi Endowed Professor
Second Affiliated Hospital of Zhejiang University
The melanocortin-1 receptor (MC1R), a G-protein-coupled receptor, has a crucial role in human and mouse pigmentation. Individuals carrying MC1R variants, especially those associated with red hair color, fair skin and poor tanning ability (denoted as RHC variants), are associated with higher risk of melanoma. We reported that MC1R controls UVB-induced G1- like cell cycle arrest and subsequent onset of premature senescence in melanocytes, abrogation of which contributes to melanoma development. Mechanistically, we demonstrated that WT-MC1R stabilized PTEN against proteolytic degradation under UV exposure, resulting in inhibition of AKT phosphorylation and activation after UV exposure.
Date and Time:
ZJE building A203
Host: Prof. Suhong Xu