The agenda proposed as follows:

-welcome acting dean Prof. Guo and congratulation to Prof. Suhong as vice dean

-welcome new arriving staff

-pandemic control in Haining

-teaching activity （UG programme progress）

-progress of PG (dual degree and UoE single degree student recruitment)

-progress of research (funding and core facility)

浙江大学爱丁堡大学联合学院“爱浙谭iZJEer Talk” 主题座谈会第六期将于4月20日在学院102会议室举行。本期由学院常务副院长郭国骥与师资代表进行面对面交流，十多位中外师资参与座谈。

为进一步助力学生学习生活，同时畅通学生参与ZJE民主管理的渠道，学院邀请学院研究生同学代表于2022年4月14日（周四）晚17：00-18：00，于ZJE大楼A123会议室参加”爱浙谭“ iZJEer Talk座谈会，听取和了解同学们对学院发展的相关意见和建议。

为进一步助力学生学习生活，同时畅通学生参与ZJE民主管理的渠道，学院邀请同学们于2022年3月31日（周四）晚17：00-18：00，于ZJE大楼A102会议室参加”爱浙谭“ iZJEer Talk座谈会，听取和了解同学们对学院发展的相关意见和建议。

ROS-responsive polymers for tissue repair and regeneration via modulating inflammation microenvironment

Prof. Changyou Gao

FBSE, AIMBE fellow, Qiushi Distinguished Professor

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, International Research Center for X Polymers, Department of Polymer Science and Engineering, Zhejiang University

Abstract:

The degree of tissue injuries such as the level of scarring or organ dysfunction, and the immune response against them primarily determine the outcome and speed of healing process. In the tissue repair and regeneration processes, different types of biomaterials are implanted either alone or by combined with other bioactive factors, which will interact with the immune systems including immune cells, cytokines and chemokines etc. to achieve different results highly depending on this interplay. Several types of polymers including polyurethane elastomers and hydrogels responding to reactive oxygen species (ROS) have been synthesized and integrated with other functional molecules for the treatment of myocardial infarction, osteoarthritis (OA) and lung inflammation etc. in vivo. These materials systems could effectively alleviate the inflammation microenvironment of tissues, and modulated the macrophages toward anti-inflammatory M2 polarization, and thereby could better restore the normal tissue microenvironment and achieve better tissue repair and regeneration outcome. 

Date and Time 

10 March  15:30-16:30

A203-1，ZJE building

Host : Dr. Wenwen Huang

为进一步助力学生学习生活，同时畅通学生参与ZJE民主管理的渠道，学院邀请2020级本科生于2022年3月3日（周四）晚17：00-18：00，于ZJE大楼A123会议室参加”爱浙谭“ iZJEer Talk座谈会，听取和了解同学们对学院发展的相关意见和建议。

Xin-Hua Feng

AAAS Fellow

National Distinguished Professor 

Zhejiang Distinguished Expert

Zhejiang University Qiushi Chair Professor 

Director, Life Sciences Institute, Zhejiang University

Title:

To TGF-b or not to TGF-b, that is the question in cancer and development. 

Abstract:

TGF-b, BMPs and related cytokines play essential roles in normal development. In physiological settings, strength and duration of TGF-b signaling are tightly and precisely controlled. I am going to share two stories. The first story is on TGF-b signaling: how tumor cells develop strategies to escape from TGF-b anti-growth control. It has been known that one mechanism to resist the cytostatic effect of TGF-b is through inactivating mutations/deletions of genes in the TGF-bsignaling pathway such as Smad4, which frequently occur in gastrointestinal and pancreatic cancer. However, deletion or mutations in the Smad4 gene are rare in other types of cancers. We have found that TGF-b signaling could be impaired by ALK that phosphorylates Smad4 on tyrosine and inactivates the latter’s tumor suppressor activity. The second story is on BMP signaling: how BMP signaling is attenuated by lysosomal degradation of the BMP type I receptor. an ER-resident LC3-binding protein interacts with the type I BMP receptor (BMPR1) and causes the receptor degradation through the autophagosome, thereby impacting intestinal crypt regeneration. Our novel studies gain molecular insights into TGF-bsuperfamily signaling in development and tumorigenesis.

Date: March 2nd, 2022

Time: 15:30-16:30

Host: Wanlu Liu, Qianting Zhang

Dr Vasso Makrantoni

Lecturer in Infection Medicine ，UoE 

Dr. Vasso Makrantoni  is a Lecturer in Infection Medicine at the University of Edinburgh and holds a joint appointment at the Zhejiang University – University of Edinburgh Institute ( ZJU-UoE). Her research focusses on how human fungal pathogens, in particular Candida albicans, remodel their genome in order to adapt in diverse environmental niches, and acquire antifungal drug resistance. Her lab uses genetics, genomics, live-cell-imaging and biochemistry to understand the molecular mechanisms that control genome remodelling in pathogen-host interaction systems and Candida clinical  isolates. Vasso, obtained her PhD degree from St Andrews University, and carried out postdoctoral work with Prof. Mike Stark at the Wellcome Centre, University of Dundee and Prof. Adele Marston at the Welcome Centre for Cell Biology, Edinburgh. In 2021 she moved to Infection Medicine in Edinburgh to establish her independent research group.

Host：Dr. KuanYoow Chan

Time: Thursday the 24th February 2022 16:30-17:30

A203-1

为进一步助力学生学习生活，同时畅通学生参与ZJE民主管理的渠道，学院邀请同学们于2022年2月17日（周四）晚17：00-18：00，于ZJE大楼A102会议室参加”爱浙谭“ iZJEer Talk座谈会，听取和了解同学们对学院发展的相关意见和建议。

Xin-Hua Feng

AAAS Fellow, National Distinguished Professor, Qiushi Chair Professor

Director of Life Sciences Institute

Zhejiang University

Title:

To TGF-or not to TGF-, that is the question in cancer and development

Abstract:

TGF-, BMPs and related cytokines play essential roles in normal development. In physiological settings, strength and duration of TGF- signaling are tightly and precisely controlled. I am going to share two stories. The first story is on TGF-signaling: how tumor cells develop strategies to escape from TGF- anti-growth control. It has been known that one mechanism to resist the cytostatic effect of TGF- is through inactivating mutations/deletions of genes in the TGF-signaling pathway such as Smad4, which frequently occur in gastrointestinal and pancreatic cancer. However, deletion or mutations in the Smad4 gene are rare in other types of cancers. We have found that TGF- signaling could be impaired by ALK that phosphorylates Smad4 on tyrosine and inactivates the latter’s tumor suppressor activity. The second story is on BMP signaling: how BMP signaling is attenuated by lysosomal degradation of the BMP type I receptor. an ER-resident LC3-binding protein interacts with the type I BMP receptor (BMPR1) and causes the receptor degradation through the autophagosome, thereby impacting intestinal crypt regeneration. Our novel studies gain molecular insights into TGF- superfamily signaling in development and tumorigenesis.

Date and Time

1 Dec 2021, 15:30-16:30

Room A203-1, ZJE building

Host: Dr. Wanlu Liu, Dr.Qianting Zhang

Talk title:

Genetic Switches for Precision Medicine

Speaker Name and Position and Institute:

Haifeng Ye

Vice Dean and Professor of School of Life Sciences

East China Normal University

Speaker introduction or talk content:

Dr. Haifeng Ye received his Ph.D degree and completed his Postdoctoral Research from Swiss Federal Institute of Technology Zurich (ETH Zürich). He has been awarded the “ETH Silver Medal” at ETH Zürich in 2013. He started his own group in the School of Life Sciences at East China Normal University (ECNU) in 2014 and established the Biomedical Synthetic Biology Research Center in 2019 at ECNU. In 2020, he was named the Wan Ren Scholar Distinguished Professor. His research interest has been focused on synthetic biology and biomedical engineering with the goal to achieve precise diagnosis and treatment of diseases. His research topics include optogenetics-based precision medicine, synthetic gene circuits for gene- and cell-based precision therapy, synthetic biology-based cancer therapy and precise controlled gene editing. His research work was published in the top scientific journals: Science, Science Translational Medicine, Science Advances, Nature Biotechnology, Nature Biomedical Engineering, Nature Chemical Biology, Nature Communications, Proc Natl Acad Sci USA, etc.

Date and Time

17th Nov 2021, 15:30-16:30

Room A203-1, ZJE building

Host: Dr. Jian Liu

Talk title:

Cell fate control at the chromatin level

Speaker Name and Position and Institute:

Duanqing Pei

Chair Professor of Regenerative Biology

School of Life Sciences，Westlake University

Speaker introduction or talk content:

Dr. Duanqing received his PhD from the University of Pennsylvania in 1991; trained as a postdoctoral fellow at University of Michigan from 1991 to 1996. Dr. Pei began his independent research career in 1996 as Assistant Professor at the University of Minnesota School of Medicine, and was promoted to Associate Professor with tenure in 2002. Then, he joined immediately the Medical Faculty at Tsinghua University. He moved to the Guangzhou Institutes of Biomedicine and Health (GIBH) in 2004. While pursuing his scholarly work, he has been active in building various institutions and organizations including GIBH, GDL (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Hong Kong Center for Regenerative Medicine and Health. Dr. Pei was elected as Associate Member of EMBO in 2018. Dr. Pei’s primary interest is to understand cell fate control. His lab has made many pioneer and fundamental discoveries in reprogramming.

Date and Time

27 October 2021, 15:30-16:30

Room A203-1, ZJE building

Host: Dr. Di Chen

1.Talk title:

Cytoskeletal reorganization and membrane dynamics in synaptic development and plasticity

2.Speaker Name and Position and Institute:

Dr. Jia-Jia Liu

Principal investigator, Institute of Genetics and Developmental Biology

Chinese Academy of Sciences

3.Speaker introduction or talk content:

Dr. Liu received her bachelor’s degree from Wuhan University, master’s from Shanghai Institute of Cell Biology, Chinese Academy of Sciences, and PhD from the University of Chicago. Dr. Liu is currently an investigator at Institute of Genetics and Developmental Biology, Chinese Academy of Sciences. The primary research interest of her group is neuronal cell biology, focusing on the molecular and cellular mechanisms for neural activity-dependent receptor trafficking, lipid metabolism and membrane remodeling, and their physiological functions in synaptic plasticity and higher brain functions.

Date and Time

20 September 2021, 15:30-16:30

Room A203, ZJE building

Host: Dr. Zhi Hong

浙江大学爱丁堡大学联合学院2021级新生开学典礼将于9月12日早上进行，欢迎师生前来参加

真诚邀请您参加6月22日 ZJE 2021届本科生毕业晚会，一起见证这个重要时刻。