Systems Virology and Immunology

Prof. Ren Sun

Chair professor and Director of Center for Infectious Disease Research.

School of Life Sciences, Westlake University.

Professor Ren Sun takes systems biology approaches to address critical interactions between virus and host. His lab has integrated genomics, proteomics, structural biology to characterize biological processes at both population and single virus/cell levels. His team has developed a method that can generate functional maps of entire viral genomes at single nucleotide resolution. It lays the foundation for comprehensively defining virus-host interactions, and enables engineering virus for rational vaccine design. The approach was demonstrated with influenza virus in vitro and in vivo: when the immune-evasion functions were systematically identified and removed from the viral genome, the engineered viruses became more immunogenic than the wild type, but severely attenuated in vivo. Thereby, it can be a general rational approach to develop therapeutic or prophylactic vaccine for many pathogens. His team is also developing high-throughput technology platforms to map epitope-specific antibody responses, to systematically define the immunome of hosts post infection or vaccination. These technology platforms will be also applied to studies on allergy, auto-immune diseases and neuroimmunology.

Date and Time: 12 Oct. 2022, 15:30-16:30

Room A203-1, ZJE building

Host：Dr. Liu Wanlu

The axolotl’s journey to the modern molecular era

Prof. JiFeng Fei

Doctoral supervisor

Guangdong Provincial People’s Hospital/ Guangdong Academy of Medical Sciences

Prof. JiFeng Fei is a Guangdong Pearl River Scholar Distinguished Professor, member of the Youth Committee and Developmental Biology Committee of the Chinese Society for Cell Biology. He has long been engaged in using animal organisms to generate disease models to study the mechanisms of central nervous system development and regeneration. In recent years, he mainly focused on a vertebrate model Mexican axolotls to elucidate its molecular and cellular mechanisms of tissue regeneration using functional genomics, single-cell sequencing, spatial transcriptomics, living-imaging and drug screening approaches, which may provide feasible strategies to improve limited regenerative capacity in mammals. He has published more than 20 research articles in peer reviewed journals, including Nature, Science, Nature Commun, Nature Protoc, PNAS, PLoS Biol and Cell Rep.

Date and Time: 28 Sept. 2022, 15:30-16:30

Room A203-1, ZJE building

Host：Dr. Wang Chaochen

你好新生，再见朋友

Talk title：The metabolic disorder of T cells leads to neurological and bowel diseases

Jin Jin

Professor, Doctoral supervisor

Life Sciences Institute, Zhejiang University

Introduction：Jin Jin is a Professor of Immunology at the Life Sciences Institute, Zhejiang University, China. He received his B.S. and PhD from University of Science and theology of China and China Agricultural University, respectively. He moved to University of Texas, MD Anderson Cancer Center, as a Postdoctoral Fellow in 2010. He joined Zhejiang University in 2015 as a professor. Professor Jin Jin currently serves as the vice chairman of the Youth Committee of the Chinese Immunological Society, the vice chairman of the Animal Immunology Branch of the Zhejiang Immunological Society.His primary research interests are focused on the regulation and function of immune responses in the brain-gut microenvironment. Professor Jin Jin has published more than 40 research papers in high-impacted journals, including more than 10 research papers in Cell, Immunity, J Clin Invest, J Exp Med (2018, 2021), Nat Commun, J Autoimmun, Sci Adv, ABBS, CMI and other journals as a corresponding author after returning to China.

Date and Time : 14 Sept. 2022, 15:30-16:30

Room A203-1, ZJE building

Host：Dr. Wang Chaochen

欢迎加入ZJE

欢迎2022级新生们加入国际校区

欢迎老师同学们参与2022届毕业生晚会

祝福毕业生们毕业快乐前程似锦！

Talk title：Host-microbial interactions and lipid metabolism

Yuhao Wang

PI , Doctoral supervisor

Institute of Translational Medicine, School of Medicine, ZJU

Introduction：Dr. Yuhao Wang received his Ph.D degree and completed his postdoctoral research from the University of Texas Southwestern Medical Center at Dallas. In 2020, he was named National High-level Young Scholar and Zhejiang University “Hundred Talents Program” Scholar. In the same year, he started his own group in the Institute of Translational Medicine at Zhejiang University School of Medicine. Dr. Wang’s research interest is to explore the interactions between host and intestinal microbiota, especially focusing on understanding of the molecular mechanisms by which the microbiota regulates host lipid metabolism. His research achievements include the finding of microbiota regulation of lipid metabolism through the circadian clock machinery, and the discovery of transcription factor NFIL3 as an essential host factor by which connects the microbiota and metabolism, etc. These findings were published in scientific journals such as Science, PNAS and eLife. One of these publications was awarded as “Top Gut Microbiota Paper of The Year” by the American Gastroenterological Association.

Date and Time : 26 May 2022, 15:30-16:30

Room A203-1, ZJE building

Host：Dr. Wang Chaochen

The agenda proposed as follows:

-welcome acting dean Prof. Guo and congratulation to Prof. Suhong as vice dean

-welcome new arriving staff

-pandemic control in Haining

-teaching activity （UG programme progress）

-progress of PG (dual degree and UoE single degree student recruitment)

-progress of research (funding and core facility)

浙江大学爱丁堡大学联合学院“爱浙谭iZJEer Talk” 主题座谈会第六期将于4月20日在学院102会议室举行。本期由学院常务副院长郭国骥与师资代表进行面对面交流，十多位中外师资参与座谈。

为进一步助力学生学习生活，同时畅通学生参与ZJE民主管理的渠道，学院邀请学院研究生同学代表于2022年4月14日（周四）晚17：00-18：00，于ZJE大楼A123会议室参加”爱浙谭“ iZJEer Talk座谈会，听取和了解同学们对学院发展的相关意见和建议。

为进一步助力学生学习生活，同时畅通学生参与ZJE民主管理的渠道，学院邀请同学们于2022年3月31日（周四）晚17：00-18：00，于ZJE大楼A102会议室参加”爱浙谭“ iZJEer Talk座谈会，听取和了解同学们对学院发展的相关意见和建议。

ROS-responsive polymers for tissue repair and regeneration via modulating inflammation microenvironment

Prof. Changyou Gao

FBSE, AIMBE fellow, Qiushi Distinguished Professor

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, International Research Center for X Polymers, Department of Polymer Science and Engineering, Zhejiang University

Abstract:

The degree of tissue injuries such as the level of scarring or organ dysfunction, and the immune response against them primarily determine the outcome and speed of healing process. In the tissue repair and regeneration processes, different types of biomaterials are implanted either alone or by combined with other bioactive factors, which will interact with the immune systems including immune cells, cytokines and chemokines etc. to achieve different results highly depending on this interplay. Several types of polymers including polyurethane elastomers and hydrogels responding to reactive oxygen species (ROS) have been synthesized and integrated with other functional molecules for the treatment of myocardial infarction, osteoarthritis (OA) and lung inflammation etc. in vivo. These materials systems could effectively alleviate the inflammation microenvironment of tissues, and modulated the macrophages toward anti-inflammatory M2 polarization, and thereby could better restore the normal tissue microenvironment and achieve better tissue repair and regeneration outcome. 

Date and Time 

10 March  15:30-16:30

A203-1，ZJE building

Host : Dr. Wenwen Huang

为进一步助力学生学习生活，同时畅通学生参与ZJE民主管理的渠道，学院邀请2020级本科生于2022年3月3日（周四）晚17：00-18：00，于ZJE大楼A123会议室参加”爱浙谭“ iZJEer Talk座谈会，听取和了解同学们对学院发展的相关意见和建议。