On April 29, 2025, the 134th Biomed-X Research Seminar of the Zhejiang University-University of Edinburgh Institute (ZJE) was successfully held in the Room 2A-203. Invited by Prof. Di Chen, Prof. Shi-Qing Cai from the Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), delivered an academic report titled "Neural Basis of Healthy Aging". The report was hosted by ZJE postdoc Zang Xiao.
Prof. Cai explored the molecular mechanisms of healthy aging and ion channel regulation. He noted that “longevity” doesn’t equate to “youthfulness”, and healthy aging is both a scientific and social issue. Using C. elegans as a model, his team found global wild-type C. elegans show significant behavioral aging differences due to the SNP of the neuropeptide RGBA-1 and receptor NPR-28 gene. In C. elegans aging, the decline of neurotransmitter systems (serotonin/dopamine) is linked to reduced BAS-1 expression. Genetic screening identified BAZ-2/BAZ2B and SET-6/EHMT1 as epigenetic factors affecting aging across species by regulating mitochondrial function. Notably, BAZ2B is overexpressed in MASH, offering a new therapeutic target.
During the event, faculty and students actively engaged in discussions, demonstrating their open-minded approach to academic exploration and critical thinking about research questions. Prof. Cai patiently and thoroughly answered every question, deepening the understanding and insights of participants in this field.
As the 134th session of the Biomed-X Seminar series, this report underscores the institute's commitment to fostering high-level academic exchanges through its academic brand building efforts. The institute will continue to provide a platform for faculty and students to engage in cutting-edge scientific discussions.
