ROS-responsive polymers for tissue repair and regeneration via modulating inflammation microenvironment
Prof. Changyou Gao
FBSE, AIMBE fellow, Qiushi Distinguished Professor
MOE Key Laboratory of Macromolecular Synthesis and Functionalization, International Research Center for X Polymers, Department of Polymer Science and Engineering, Zhejiang University
Abstract:
The degree of tissue injuries such as the level of scarring or organ dysfunction, and the immune response against them primarily determine the outcome and speed of healing process. In the tissue repair and regeneration processes, different types of biomaterials are implanted either alone or by combined with other bioactive factors, which will interact with the immune systems including immune cells, cytokines and chemokines etc. to achieve different results highly depending on this interplay. Several types of polymers including polyurethane elastomers and hydrogels responding to reactive oxygen species (ROS) have been synthesized and integrated with other functional molecules for the treatment of myocardial infarction, osteoarthritis (OA) and lung inflammation etc. in vivo. These materials systems could effectively alleviate the inflammation microenvironment of tissues, and modulated the macrophages toward anti-inflammatory M2 polarization, and thereby could better restore the normal tissue microenvironment and achieve better tissue repair and regeneration outcome.
Date and Time
10 March 15:30-16:30
A203-1，ZJE building
Host : Dr. Wenwen Huang
